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C10H12N4O5 A compound occurring in muscle; a hydrolysis product of inosinic acid.



(hypoxanthine riboside), a nucleoside consisting of the nitride purine base hypoxanthine and the carbohydrate ribose. Inosine is the intermediate product of nucleic acid metabolism. It is formed in the organism during the deamination of adenosine and also by synthesis from a free base according to the reaction hypoxanthine + ribose- 1 -phosphate ⇆ inosine + phosphate. This reversible reaction is catalyzed by the enzyme nucleoside phosphorylase.

References in periodicals archive ?
Inosine monophosphate dehydrogenase activity in renal allograft recipients during mycophenolate treatment.
This suggests that MPNs were preferentially methylated by thiopurine methyltransferase between 6 and 20 h, rather than converted by inosine monophosphate dehydrogenase and guanosine monophosphate synthetase into TGNs.
Pharmacodynamic assessment of mycophenolic acid-induced immunosuppression by measurement of inosine monophosphate dehydrogenase activity in a canine model.
Its immunosuppressive activity is thought to reside in the inhibition of inosine monophosphate dehydrogenase (IMPDH), leading to a suppression of purine nucleotide synthesis in lymphocytes, thereby suppressing cell mitosis (3, 4).
MPA selectively and reversibly inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme that plays a pivotal role in synthesis of new DNA.
MPA mediates its effect by inhibiting inosine monophosphate dehydrogenase (1MPDH), an enzyme involved in the de novo biosynthesis of purine nucleotides [14,15].
Effect of human T lymphocyte activation on inosine monophosphate dehydrogenase expression.