Bae et al., "Hybrid cellular spheroids from hepatocellular carcinoma and insulin-secreting cell
lines," Transplantation Proceedings, vol.
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells
Research teams at the Rambam Medical Center, the Rappaport Research Institute, and the Technion in Haifa, Israel, have reported the identification of human insulin-secreting cells
derived from embryonic stem cells.
Nerve cells have successfully reversed the progression of the equivalent of multiple sclerosis in mice and have restored function to the limbs of partially paralyzed rats; and insulin-secreting cells
have normalized blood glucose in diabetic mice.
The procedure requires only two 20-minute visits to administer the required amount of insulin-secreting cells
. The Juvenile Diabetes Foundation calls the research "a very significant step forward in curing Type 1 diabetes," and, along with the National Institutes of Health (NIH), will provide financial backing for broader trials across North America and Europe.
Type I diabetes is the result of self-destruction of the insulin-secreting cells
by the body's immune system.
The researchers long-term goal is to replace insulin shots and blood sugar measurements with insulin-secreting cells
capable of automatically secreting insulin in response to the blood sugar level.
Gurgul-Convey, "Effects of the novel mitochondrial protein mimitin in insulin-secreting cells
," Biochemical Journal, vol.
The patent is for a method of producing insulin-secreting cells
from stem cells, and it is likely to constitute the foundation for the company's products in the field of stem-cell based treatment of diabetes.
Previous studies including ours have found that palmitate increases death in different insulin-secreting cells
including MIN6 cells and isolated human islets cultured with palmitate for 48 hrs [13, 16, 18, 20, 37].
Melton's lab generated millions of insulin-secreting cells
from human embryonic stem cells (hESC, which require the destruction of a young human being) and from human induced pluripotent stem cells (hiPSC, the stem cells created from normal skin cells, without using embryos).
To investigate the mechanism underlying this protective action of baicalein, we assessed whether baicalein affects the viability of insulin-secreting cells
and human islets.