Using integrative bioinformatics
and analyses of data from more than 1,200 patients, the BII scientists found that a 22-gene panel could be used to classify IDC cases into two new major classes that reflect the aggressiveness of the tumours, namely Low Genetic Grade (LGG) and High Genetic Grade (HGG).
The goal has now shifted from an individual result to the capturing of the global picture of entire biological system using the approach of Integrative Bioinformatics
The patients tumours will be classified into molecular subtypes based on their molecular profile by use of high-throughput technologies (sequencing, RPPA) combined with integrative bioinformatics
Funding: National Institutes of Health, Early Detection Research Network, Prostate Specialized Program of Research Excellence (SPORE), National Center for Integrative Bioinformatics
, National Center for Functional Genomics, U.
Transforming data into information and turning information into knowledge is a major challenge for integrative bioinformatics
, and is the key to understanding the complexities of biological and molecular clinical research.