integrin


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integrin

[in′teg·rən]
(cell molecular)
A heterodimeric transmembrane receptor protein of animal cells that binds to components of the extracellular matrix on the outside of a cell and to the cytoskeleton on the inside of the cell, functionally connecting the cell interior to its exterior; in blood cells, integrins are also involved in cell-cell adhesion.
References in periodicals archive ?
The alpha4beta7 integrin is expressed on a subset of circulating white blood cells that have been shown to play a role in mediating the inflammatory process in UC and CD.
Three leukocyte adhesion deficiency (LAD) disorders have been well recognized, caused by genetic defects in Beta 2 integrin family consist of LFA-1 (CD11a/CD18), Mac-1 (CD11b/CD18), Complement receptor 4 (CD11c/CD18), and (CD11d/CD18).
Among known integrins, integrin a[sub]v[sz]3 is the most important because it is abundant in superficial cells and neovascular endothelial cells of multiple tumors and participates in tumor angiogenesis.
4), CIB2 likely interacts with the membrane-proximal domain of the integrin [alpha]7B subunit ([alpha] 7B-M) and previous studies also proposed C-terminal end fragment ([alpha] 7B-C).
Extending from the tip of the STM was another electrode attached to a small molecule, called a ligand, which specifically binds to the integrin protein.
United States-based Allegro Ophthalmics' Luminate integrin peptide therapy has passed a phase two trial in diabetic macular oedema (DME) patients by meeting its primary endpoint when used as a sequential treatment, it was reported yesterday.
0mM resulted in stratification as well as differentiation and stratification is generally held to involve the reduction in the affinity of the extracellular matrix receptors, the integrin for their ligands, which include FN.
The company was founded to exploit the therapeutic potential of RGD-binding integrin antagonists by leveraging groundbreaking discoveries on the role of these integrins in the pathogenesis of fibrosis.
These effects are mediated via integrin receptor for the thyroid hormones on the vascular smooth muscle cells and endothelial cells reflecting the relation between genomic and non-genomic mechanisms invoked by the thyroid hormones.
Furthermore, when they artificially activated integrin in mice with aged muscles, their regenerative abilities were restored to youthful levels.
3] integrin promoting cell motility and activation of small GTPases, such as Cdc42 and Rac1, which can lead to podocyte contraction, shifting from a stationary to motile phenotype and leading to foot process effacement and proteinuria (Figure 1) [45].