integrin

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integrin

[in′teg·rən]
(cell molecular)
A heterodimeric transmembrane receptor protein of animal cells that binds to components of the extracellular matrix on the outside of a cell and to the cytoskeleton on the inside of the cell, functionally connecting the cell interior to its exterior; in blood cells, integrins are also involved in cell-cell adhesion.
References in periodicals archive ?
Leukocyte adhesion deficiency type I (LAD-1) is an autosomal recessive disorder characterized by severe and recurrent bacterial infections, altered wound healing and significant morbidity that is caused by absent or diminished expression of integrins b2 class.
Bad cholesterol (low-density lipoprotein or LDL) controls the trafficking of tiny vessels which also contain these integrins, and this has huge effects on the ability of cancer cells to move and spread throughout the body,' said Thomas Grewal, an associate professor from University of Sydney.
Integrins are heterodimers (ie, they consist of an [alpha] and [beta] subunit).
Methods: Metastasis-associated MR molecular imaging probe, integrin a[sub]v[sz][sub]3ligand cRGD-PEG-DGL-DTPA-Gd (Gd-RGD), were constructed.
Integrins allow the cells to interact with extracellular molecules and become triggered to expand in numbers before eventually producing a large pool of mature dental cells.
Most of these receptors belong to integrin receptor family.
The new organisation unites Antegrin's portfolio of small-molecule integrin antagonists with the drug-development expertise, seasoned executive experience, and track record of Cascadia.
Integrins are proteins that 'integrate' the outside to the inside of the cell, providing a connection to the immediate external environment, and without them, almost every stage of the regenerative process is disrupted.
Researchers now think blocking the movement of integrins from outside to inside the cells could combat the disease spreading.
The Role of uPAR Signaling and Integrin Activation in Podocytes and Proteinuric Kidney Diseases
Integrins [alpha]6 and [beta]1 were observed along the basement membrane, and the staining of both integrins [alpha]6 and [beta]1 was significantly increased at dose-dependent manner (Figures 2 and 3).
HPeV1 binds to two integrins, aVE-3 and aVE-6, via its RGD motif located in VP1 on the capsid.