Pemphigus is an uncommon autoimmune condition in which circulating autoantibodies against intercellular adhesion molecules
result in acantholysis, or loss of keratinocyte adhesion.
Table-1: Comparison of intercellular adhesion molecules
between cases and controls.
The cytokines, IL-1beta and TNF, on the other hand, induce the synthesis and upregulated expression of the endothelial adhesion molecules E-selectin, intercellular adhesion molecules
(ICAMs)-1 and -2, and vascular adhesion molecule (VCAM)-1.
Intercellular adhesion molecules
(ICAM-1) and Vascular cell adhesion molecules (VCAM-1) belong to Ig superfamily and both are involved in immune reaction .
53-57) The accumulation of ROS promotes the expression of intercellular adhesion molecules
and subsequent neutrophil-endothelial cell adhesion.
Working separately, cell biologists and immunologists over the same period investigated a class of cell-surface molecules called intercellular adhesion molecules
, including one known as ICAM-1.