cell adhesion molecule

(redirected from Intercellular adhesion molecule-1)
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cell adhesion molecule

[¦sel ad‚hē·zhən ′mäl·ə·kyül]
(cell and molecular biology)
A class of membrane proteins comprising the outer surfaces of cell membranes in the developing nervous system that is thought to be intimately involved in guiding development during embryonic life. Abbreviated CAM.
References in periodicals archive ?
Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells.
Intercellular adhesion molecule-1 (ICAM-1) [1] is a widely distributed adhesion factor present on the surfaces of endothelial cells and leukocytes.
Alicaforsen is an antisense inhibitor of Intercellular Adhesion Molecule-1 (ICAM-1) that is being developed by Isis Pharmaceuticals, Inc.
announced today it has initiated a Phase III clinical trial of alicaforsen (ISIS 2302), an antisense inhibitor of intercellular adhesion molecule-1 (ICAM-1), in people with active Crohn's disease.
Nasdaq: ISIP) is developing ISIS 2302, an antisense inhibitor of intercellular adhesion molecule-1 (ICAM-1), a molecule that plays a central role in inflammation.
Associations of soluble intercellular adhesion molecule-1 with carotid atherosclerosis progression.
Intercellular adhesion molecule-1 (ICAM-1) that plays a key role in leukocyte migration and activation is upregulated on activated endothelial cells.
Among the 17 novel biomarkers that proved to have no predictive value were markers of general inflammation, including CRP, lipoprotein-associated phospholipase A2, adiponectin, and soluble intercellular adhesion molecule-1, receptor for advanced glycation end products (RAGE), and soluble vascular adhesion molecule-1.
Levels of soluble intercellular adhesion molecule-1 (ICAM-1) averaged 374 ng/mL in the metabolic syndrome group and 333 ng/mL in the comparison arm.
Adhesion molecules promote the binding and rolling of inflammatory cells (monocytes, T-lymphocytes) along stressed endothelium, and include such molecules as vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1).
Thalidomide may also increase the expression of cytoadhesion molecules in myeloma cells and in the bone marrow microenvironment, such as lymphocyte function-associated antigen-1, intercellular adhesion molecule-1, and vascular cell adhesion molcules-1.
Thromboxane mediates diapedesis after ischemia by activation of neutrophil adhesion receptors interacting with basally expressed intercellular adhesion molecule-1.

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