interleukin-11

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interleukin-11

[‚in·tər¦lük·ən i′lev·ən]
(immunology)
A pleiotropic cytokine produced by bone marrow-derived fibroblasts which supports the growth of certain cell types, such as B cells, neutrophils, and platelet-producing megakaryocytes. Abbreviated IL-11.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
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Mizoguchi, "Effect of interleukin 11 on normal and pathological thrombopoiesis," Cancer Chemotherapy and Pharmacology, vol.
Growth factors that may have an impact on mucositis are granulocyte-colony stimulating factor (G-CSF) and granulocyte macrophage-colony stimulating factor (GM-CSF), Interleukin 11 (IL-11), and keratinocyte growth factor (KGF).
Osteolytic lesions are common in patients with either localized or multisystem involvement in Langerhans cell histiocytosis (LCH).[1] Although the skull is the more frequently affected site, virtually any bone in the body can be involved.[2] Relatively recent studies have shown that human melanoma and breast cancer cells can induce bone resorption in a murine calvaria culture system through both the direct elaboration of interleukin 11 (IL-11) and by enhancing its production via the activation of the latent transforming growth factor [Beta] (TGF-[Beta])[3,4]; therefore, it was hypothesized that these 2 cytokines may be involved in the pathogenesis of the osteolytic lesions in LCH.