interleukin-12

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interleukin-12

[‚in·tər¦lük·ən ′twelv]
(immunology)
A heterodimeric cytokine that stimulates nonspecific cytotoxic natural killer-type cells to produce gamma interferon. Abbreviated IL-12.
References in periodicals archive ?
Foci of mycobacterial infection by diagnoses Focus of mycobacterial infection BCG-itis Lung tuberculosis BCG-osis Diagnosis CGD 3 5 1 IFNGR2 4 0 0 IFNGR1 1 0 0 IL12 RB1 2 0 0 SCID 4 0 0 NEMO 0 0 1 Total 14 5 2 1 Focus of mycobacterial infection Skin abscess BCG-itis and lung tuberculosis Total Diagnosis 0 3 12 0 0 4 0 0 1 0 0 2 1 0 5 0 0 1 Total 3 25 BCG: Bacille Calmette-Guerin; CGD: chronic granulomatous disease; IFNGR2: IFN-[gamma] receptor 2; IFNGR1: IFN-[gamma] receptor 1; IL12R1: interleukin 12 receptor beta 1; NEMO: nuclear factor kappa beta essential modulator SCID: severe combined immune deficiency Table 2.
Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand.
Keywords: Interleukin 12, Recurrent aphthous stomatitis, Single nucleotide polymorphisms
Antitumor and antimetastatic activity of interleukin 12 against murine tumors.
In vitro analysis demonstrated that LMS is synergistic with interleukin 12 in the induction of a Th1 cytokine response at very low concentrations (1microM).
8 Patients with progressive MS have a high percentage of Interleukin 12 producing MO in the blood compared to normal individuals.
Ustekinumab, which is approved to treat adults with moderate to severe plaque psoriasis, and the investigational psoriasis drug briakinumab inhibit interleukin 12 (IL-12) and IL-23 proteins linked to inflammation.
The drug was developed to inhibit elements of the body's immune system, Interleukin 12 and Interleukin 23.
1) One of the proteins investigated was Interleukin 12 (IL-12).
The molecule attacks, binds to, and inactivates interleukin 12 and 23.
Cytokine mRNA expression in leprosy: a possible role for interferon g and interleukin 12 in reactions (RR and ENL).