Nobata et al., "Interleukin-17
levels in Helicobacter pylori-infected gastric mucosa and pathologic sequelae of colonization," World Journal of Gastroenterology, vol.
and its expanding biological functions," Cellular & Molecular Immunology, vol.
Taanman-Kueter et al., "Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17
production in human memory T cells," Immunity, vol.
The effects of vitamin D on allergen-induced expression of interleukin-13 and interleukin-17
in cord blood [CD4.sup.+] T cells.
The role of T-cell interleukin-17
in conducting destructive arthritis: lessons from animal models.
(Levels of interleukin-17
in patients with periodontal disease).
The signature cytokine, interleukin-17
(IL-17), combined with other proinflammatory cytokines (e.g., IL-6, TNF-[alpha], IL-1, and IL-8) induced by IL-17 contributes to the promotion of disruptive enzymes such as metalloproteinase-9 [40, 42, 43].
The granted claims cover the use of these cell populations to reduce levels of inflammatory cytokines TNF-alpha, interleukin-6, and interleukin-17
, all established mediators of inflammatory arthritis in rheumatic diseases.
This growth will be driven primarily by the highly anticipated arrivals of promising systemic therapies- interleukin-17
(IL-17) inhibitors (Cosentyx, guselkumab and tildrakizumab), interleukin-23 (IL-23) inhibitors (ixekizumab and brodalumab) as well as phsophodiesterase (PDE4) inhibitor- Otezla (apremilast).
Opportunistic infections in adult patients can also be a presentation of autoantibodies that inhibit cytokines including (but not only) anti interferon-gamma (anti IFN-?) self-antibodies in previously healthy adults presenting with severe Mycobacterial infections (4) or antibodies to interleukin-17
(IL-17) and IL-22 that are associated with chronic candidiasis (5) this group of autoantibodies are now recognized as phenocopies or acquire immune disorders resembling primary genetic immunodeficiency diseases (6).
mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis.
Functional specialization of interleukin-17