interleukin

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interleukin

a substance extracted from white blood cells that stimulates their activity against infection and may be used to combat some forms of cancer

interleukin

[‚in·tər′lü·kən]
(immunology)
Any of a class of proteins that are secreted mostly by macrophages and T lymphocytes and induce growth and differentiation of lymphocytes and hematopoietic stem cells.
References in periodicals archive ?
Interleukin 6 and interleukin 8 are the much studied cytokines as they are essential mediators of cancer development and powerful activators of apoptotic and anti-apoptotic signaling cascade.16 IL-8 is found to stimulate angiogenesis, influence tissue remodeling, leukocyte chemotaxis, dysregulated cell cycle, suppressed immune system and regulating of cell proliferation and differentiation.17 Various stimuli for example chemical and environmental stresses including chemotherapy and hypoxia, proinflammatory cytokines like TNF-[alpha] and IL-1, hormones and bacterial and viral products are known to regulate the manifestations of IL-8.18
This is in contrast to findings by workers elsewhere that suggest the suppression of interleukin levels was without respect to the ART regimen used [11, 13].
A lot of research has been carried out on creatine and interleukin role in and/or after HIE but this is for the first time that a relationship between interleukin levels in blood sera and administration of different concentrations of Cr as a treatment for HI has been established.
Also released are other interleukin related cytokines detection kits:
Paul, "Interleukin 4: signalling mechanisms and control of T cell differentiation," CIBA Foundation Symposia, no.
The stimulants/melatonin solution caused interleukin levels to increase significantly in all three subject groups compared to when cells were exposed to stimulants alone.
(2007) demonstrated that chemically induced liver damage in mice led to the MyD88-associated production of interleukins. Increases in serum interleukin, made by liver macrophages, resulted in an innate immune response in liver cancers through MyD88.
Interleukins are part of the larger immune response to injury in which proinflammatory cytokines are sent to the site of trauma or injury to make repairs and begin the healing process.
Researchers have named the 15 known interleukins in the order in which they were discovered.
Certain cells release these messenger molecules, called interleukins, to regulate the growth, differentiation, or proliferation of immune-system white blood cells that defend the body against infections.
Studies have shown that polymorphism of genes encoding both IL-18R and the IL-18 interleukin in some variants may predetermine both the development of OA and lumbar disc degeneration (LDD) [164,165].