Goetghebeur (1986) already doubted the value of this trait, but since the invagination
above the root cap seemed to be an important characteristic in other embryo types, he distinguished a Websteria-type.
However, in patients who have celiac disease and do not receive any treatment, it has been reported in recent years that invagination
is seen as a rare clinical finding of the disease (3).
The deletion of both Fgf3 and Fgf10 has revealed that the development of molar is inhibited prior to the bud stage, suggesting possible compensations between Fgf3 and Fgf10 during invagination
of the dental epithelium [79, 80].
Benign causes, such as a relatively more dilated proximal appendiceal lumen relative to the distal portion, mobile appendicular wall resulting in active peristalsis, or invagination
of the appendiceal stump following appendectomy, are leading causes of appendiceal intussusception .
At stage 17, the Mullerian duct appears via a deep invagination
at the level of the 3rd thoracic somite and proceeds to grow caudally towards the Wolffian ducts until fusion in stage 18.
A clinical diagnosis of obstructive defecation syndrome (Wexner constipation score = 14) and anterior anal fissure was made; the patient was then subject to colonoscopy and defecography that showed an anterior rectocele with an ampullary invagination
Histopathology showed epidermal acanthosis, deep epidermal invagination
of a parakeratotic column (cornoid lamella), which is distinctive feature of PEODDN with absent granular layer .
Histological examination showed multiple, keratin-filled invagination
, a parakeratotic column (i.e., cornoid lamella), a loss of the granular layer of the underlying epidermis, and dense lympho-histiocytic infiltrate in the dermis, compatible with porokeratosis (Fig.
An intussusception is defined as invagination
of one segment of bowel into lumen of adjacent distal segment.
A prominent parakeratotic column within an epidermal invagination
that displays loss of the granular layer is found overlaying an eccrine duct with a dilated acrosyringium.
CBCT has been shown to be particularly useful in assessing the dimension of invagination
, configuration root canal and periapical lesions of teeth presenting with endodontic problems.
Pediatric surgery consultation with abdominal ultrasonography showed no invagination
and surgical pathology was not considered.