Moreover, the ionic channel
modeling using Markov chains  is valid if the sampling time is much longer than the channel protein transition time (order of ps) .
Choosing the volume of the ionic channel
on the realistic [V.sub.TRP] [congruent to] [10.sup.-24] [m.sup.3], the dipole momentum of the channel is [p.sub.TRP] = [P.sub.TRP] = [0.sup.3] x [0.sup.02] = [0.sup.-2] Ams.
It has been demonstrated that, in addition to neurons and muscular cells, endocrine cells like somatotropes, express spontaneous electrical activity; which means that they are electrically excitable and able to produce action potentials (AP) by activation of diverse populations of voltage-sensitive ionic channels
. It is well established that voltage-gated ion channels are involved in the control of the excitation-secretion coupling that leads to hormone release in different pituitary hormone-secreting cell types, including somatotropes .
glauca could be due in part to the action of GB through a mechanism involving the participation of ionic channels
or the regulation of the GAB[A.sub.A] receptor in a different place than that for benzodiazepines.
where [I.sub.ion] is Hodgkin-Huxley type ionic current, as we have in the presynaptic region while [I.sub.X] is synaptic current through ionic channels
. The postsynaptic current occurs as a result of rise and fall in potential caused by the firing of the presynaptic neuron.
Neuronal nicotinic acetylcholine receptors (nAChRs) belong to the pentameric superfamily of Cys-loop ligand gated ionic channels
. They are composed of either homomeric a or heteromeric [alpha] and [beta] subunits assembled from a family of 12 distinct neuronal nicotinic subunits ([alpha]2-[alpha]10; [beta]2-[beta]4) .
Not much is known about the effects of lignans on ionic channels
. Heteroclitin D and gomisin J have been shown to inhibit cardiac L-type voltage-gated [Ca.sup.2+] channels (Zhang et al.
Tables summarize clinical trials with drugs targeting ionic channels
, antiporters, and pumps in ischemic stroke.
The brain's unique proteins glue the neuron-silicon chip together, providing the "link between the ionic channels
of the neurons and semiconductor material in a way that neural electrical signals could be passed to the silicon chip," says Vassanelli.
They refer that the scorpion toxins probably act in the ionic channels
at cellular membrane level.
This is in part because of advances in understanding the chemical messengers (neurotransmitters) released by nerve cells and voltage-generating proteins (ionic channels
) housed on nerve-cell membranes that participate in the transmission of normal sensation.
But the electricity in the ionic channels
can zip through the thin glass dead-end without harming the device in the process.