Enzyme Inhibitor

(redirected from Irreversible inhibition)
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Enzyme Inhibitor

 

a chemical substance that selectively inhibits the activity of an enzyme or a group of related enzymes. Even in very low concentrations, enzyme inhibitors repress an organism’s vital physiological functions. Many toxic substances, including pesticides, such nerve gases as lewisite, and such respiratory toxins as cyanides and hydrogen sulfide, have a toxic effect owing to the inhibition of enzymes, for example, the enzyme cholinesterase in arthropods.

The study of the effect of enzyme inhibitors on enzymes or groups of enzymes facilitates the search for antidotes or for new pesticides to control harmful insects, mites and ticks, and weeds. The term “enzyme inhibitors” sometimes refers to enzymes in the poisons of snakes, bees, and scorpions that destroy tissues or blood cells in man and animals.

References in periodicals archive ?
Part 7: Assay and characterization of 7,8-diacetoxy-4-methylcoumarin:protein transacetylase from rat liver microsomes based on the irreversible inhibition of cytosolic glutathione Stransferase.
Acetyl-CoA protection assays indicated that Cd-dependent irreversible inhibition of human NAT1 and NAT2 was due to the reaction of the metal with the reactive catalytic cysteine residue (Ragunathan et al.
RNOS are generally thought to cause deleterious effects such as chemical damage to proteins and DNA and irreversible inhibition of mitochondrial respiration (15, 16, 17) by modifying important biomacromolecules.
Aspirin causes irreversible inhibition of platelet function and other clotting disorders, so its use near term may result in enhanced maternal blood loss at delivery and an increase in the incidence of intracranial hemorrhage in premature or low-birthweight infants.
BRIEF BUTYLTIN EXPOSURE INDUCES IRREVERSIBLE INHIBITION OF THE CYTOTOXIC FUNCTION OF HUMAN NATURAL KILLER CELLS, IN VITRO.
With irreversible inhibition, the only way the enzyme activity can return to normal is by de novo synthesis of the enzyme by the cell," she said.
Our covalent drug platform has generated targeted small molecule inhibitors of PI3K, with specific and potent irreversible inhibition and prolonged duration of action, and activity in vivo.
a biotechnology company developing novel targeted covalent drugs, has published research in Nature Chemical Biology demonstrating the first-ever selective irreversible inhibition of a viral protease using a targeted covalent drug.