Enzyme Inhibitor

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Enzyme Inhibitor

 

a chemical substance that selectively inhibits the activity of an enzyme or a group of related enzymes. Even in very low concentrations, enzyme inhibitors repress an organism’s vital physiological functions. Many toxic substances, including pesticides, such nerve gases as lewisite, and such respiratory toxins as cyanides and hydrogen sulfide, have a toxic effect owing to the inhibition of enzymes, for example, the enzyme cholinesterase in arthropods.

The study of the effect of enzyme inhibitors on enzymes or groups of enzymes facilitates the search for antidotes or for new pesticides to control harmful insects, mites and ticks, and weeds. The term “enzyme inhibitors” sometimes refers to enzymes in the poisons of snakes, bees, and scorpions that destroy tissues or blood cells in man and animals.

References in periodicals archive ?
KEY WORDS: aromatic amine carcinogens, arylamine N-acetyltransferases, cadmium, irreversible inhibition, xenobiotic metabolism.
a biotechnology company developing novel targeted covalent drugs, has demonstrated the first-ever selective irreversible inhibition of a viral protease using a targeted covalent drug.
It was therefore thought that if the [alpha],[beta]-unsaturated ester moiety is incorporated into the basic structural frame of a simple substrate in such a way that it would bind the enzyme with its carbonyl group being coordinated to the zinc ion, then a Michael type addition reaction may occur on the [alpha],[beta]-unsaturated acid or ester by the catalysed carboxylate in ACE, leading to irreversible inhibition of the enzyme.
By using the Cloe(R) Screen mechanism-based inhibition assays in conjunction with our existing Cloe(R) Screen CYP450 inhibition assays, it is possible to investigate both reversible and irreversible inhibition.
Several large trials demonstrated improved risk reduction by dual antiplatelet therapy with aspirin and clopidogrel, a thienopyridine that causes irreversible inhibition of the platelet ADP receptor [P2Y.
Since aspirin causes irreversible inhibition of platelet function and other clotting disorders, its use near term may enhance maternal blood loss at delivery and increase the incidence of intracranial hemorrhage in premature infants.