Enzyme Inhibitor

(redirected from Irreversible inhibition)
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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Enzyme Inhibitor

 

a chemical substance that selectively inhibits the activity of an enzyme or a group of related enzymes. Even in very low concentrations, enzyme inhibitors repress an organism’s vital physiological functions. Many toxic substances, including pesticides, such nerve gases as lewisite, and such respiratory toxins as cyanides and hydrogen sulfide, have a toxic effect owing to the inhibition of enzymes, for example, the enzyme cholinesterase in arthropods.

The study of the effect of enzyme inhibitors on enzymes or groups of enzymes facilitates the search for antidotes or for new pesticides to control harmful insects, mites and ticks, and weeds. The term “enzyme inhibitors” sometimes refers to enzymes in the poisons of snakes, bees, and scorpions that destroy tissues or blood cells in man and animals.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
This nonenzymatic acetylation results in the irreversible inhibition of COX1 [45].
Acetyl-CoA protection assays indicated that Cd-dependent irreversible inhibition of human NAT1 and NAT2 was due to the reaction of the metal with the reactive catalytic cysteine residue (Ragunathan et al.
It was therefore thought that if the [alpha],[beta]-unsaturated ester moiety is incorporated into the basic structural frame of a simple substrate in such a way that it would bind the enzyme with its carbonyl group being coordinated to the zinc ion, then a Michael type addition reaction may occur on the [alpha],[beta]-unsaturated acid or ester by the catalysed carboxylate in ACE, leading to irreversible inhibition of the enzyme.
Several large trials demonstrated improved risk reduction by dual antiplatelet therapy with aspirin and clopidogrel, a thienopyridine that causes irreversible inhibition of the platelet ADP receptor [P2Y.sub.12] (1-3).
Since aspirin causes irreversible inhibition of platelet function and other clotting disorders, its use near term may enhance maternal blood loss at delivery and increase the incidence of intracranial hemorrhage in premature infants.
RNOS are generally thought to cause deleterious effects such as chemical damage to proteins and DNA and irreversible inhibition of mitochondrial respiration (15, 16, 17) by modifying important biomacromolecules.
Aspirin causes irreversible inhibition of platelet function and other clotting disorders, so its use near term may result in enhanced maternal blood loss at delivery and an increase in the incidence of intracranial hemorrhage in premature or low-birthweight infants.
BRIEF BUTYLTIN EXPOSURE INDUCES IRREVERSIBLE INHIBITION OF THE CYTOTOXIC FUNCTION OF HUMAN NATURAL KILLER CELLS, IN VITRO.
"With irreversible inhibition, the only way the enzyme activity can return to normal is by de novo synthesis of the enzyme by the cell," she said.
Adams, "Irreversible inhibition of Schizophyllum commune cellulase by divalent transition metal ions," Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular Enzymology, vol.