Rose, Irwin

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Rose, Irwin,

1926–2015, American biochemist, b. Brooklyn, N.Y., Ph.D. Univ. of Chicago, 1952. Rose was on the faculty of Yale Medical School from 1954 to 1963 and a senior member of the Fox Chase Cancer Center in Philadelphia from 1963 until 1995. After retiring he accepted (1997) a special appointment as a researcher at the Univ. of California, Irvine. In 2004 Rose shared the Nobel Prize in Chemistry with Aaron CiechanoverCiechanover, Aaron,
1947–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1974; D.Sc. Technion (Israel Institute of Technology), Haifa, 1982. He has been on the faculty at the Technion since 1986.
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 and Avram HershkoHershko, Avram,
1937–, Israeli biochemist, M.D. Hebrew Univ.–Hadassah Medical School, Jerusalem, 1965, Ph.D. 1969. Hershko has been a professor at the Rappaport Faculty of Medicine at the Technion (Israel Institute of Technology), Haifa, since 1972.
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 for their discovery of ubiquitin-mediated protein degradation. The three scientists elucidated the pathway through which protein degradation takes place in cells, and identified the molecules called ubiquitins as markers that indicate what proteins are to be broken down. Cancer and some degenerative diseases are believed to result from disruptions in this pathway.
References in periodicals archive ?
Irwin rose to international fame with his wildlife documentary show, The Crocodile Hunter, which enjoyed five successful seasons from 1997 to 2004.
Irwin rose to fame teaching people about wild animals on TV shows like Animal Planet's The Crocodile Hunter.
The Royal Swedish Academy of Sciences chose Irwin Rose, 78, of the University of California, Irvine, and Avram Hershko, 67, and Aaron Ciechanover, 57, both of the Israel Institute of Technology, in Halla, Israel, "for the discovery of ubiquitin-mediated protein degradation.
Los israelies Aaron Ciechanover y Abraham Hershko; y el norteamericano Irwin Rose ganaron el Premio Nobel 2004 de Quimica por su trabajo en torno a la busqueda de explicaciones de como las celulas producen proteinas en lo que se llama ubiquitina, de relevancia fundamental en distintos procesos de las celulas, como su division o transformacion en cancerosas.
Aaron Ciechanever, 57, and Avram Hershko, 67, of the Technion-Israel Institute of Technology in Haifa and Irwin Rose, 78, of the University of California, Irvine will share the roughly $1.
En la decada de 1980, los bioquimicos israelies Aaron Ciechanove y Avram Hershko y el bioquimico estadunidense Irwin Rose investigaron el proceso por el cual las celulas identifican y seleccionan a las proteinas defectuosas para destruirlas y preservar el buen funcionamiento del organismo.
Aaron Ciechanover and Avram Hershko of the Technion-Israel Institute of Technology in Haifa and Irwin Rose of the University of California, Irvine will share the prize, which was announced at press time.
Aaron Ciechanover, Avram Hershko and Irwin Rose for discovering and characterizing the ubiquitin pathways, which play fundamental roles in human health and disease with many human pathologies been linked to changes in ubiquitin pathway enzymes.
Aaron Ciechanover is now a Technion Distinguished Research Professor in the Rappaport Faculty of Medicine Research Institute at the Technion in Haifa, shared the Nobel Prize "for the discovery of ubiquitin-mediated protein degradation" jointly with his graduate studies mentor Avram Hershko, MD, PhD, and Irwin Rose, PhD.
advisor, and Irwin Rose, their collaborator (at that time in the Fox Chase Cancer Center in Philadelphia) for their discovery of the ubiquitin system for intracellular protein degradation http://nobelprize.
David Politzer, of Caltech; in Chemistry to Irwin Rose, UC Irvine, and in Economic Sciences to Finn E.