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Related to Isatin: Oxindole


(organic chemistry)
C6H5NO2 An indole substituted with oxygen at carbon position 2 and 3; crystallizes as red needles that are soluble in hot water; used in dye manufacture.



a heterocyclic compound; yellowish red crystals. Melting point 203.5°C. Characterized by tautomerism, isatin exists both in the lactam (I) and lactim (II) forms:

Isatin is soluble in acetone, benzene, methanol, and hot water. It exhibits mild acidic and basic properties, correspondingly forming salts with acids and bases. It is readily acylated, alkylated, nitrated, halogenated, sulfonated, and so forth.

Isatin can be obtained from aniline, by oxidation of indigo, and by other methods.

Isatin and some of its derivatives are valuable intermediates in the manufacture of indigoid vat dyes; it is also used for the detection and photometric determination of thiophene in benzene (so-called indophenine reaction), pyrrole, and mercaptans in air and for the detection of Cu and Ag. Isatin-β3-oxime, a product of the interaction of isatin with hydroxylamine, is used for the detection and determination of U and for the detection of Ag, Co, and many other elements.

References in periodicals archive ?
Anticonvulsant activity of Schiff bases of isatin derivatives.
All chemicals including isatin, solvents, metal salts and hydrazine hydrated were of analytical grade and were purchased from Sigma-Aldrich.
In the present study, immunization of rats was attained using covalent conjugates of the endogenous MAO inhibitor isatin with an antigen carrier, with consecutive immunologic and biochemical assays and behavioral analysis.
Miri, Synthesis, Biological Activity and Docking Study of Some New Isatin Schiff Base Derivatives.
The important biological activities of isatin and triazole derivatives as discussed above impelled us to take up the synthesis of these new combinational heterocycles which are likely to have augmented diverse biological activity.
The reagent 4-hydroxy-3-(2-oxoindolin-3-ylideneamino)-2-thioxo-2H-1,3-thiazin 6(3H)-one was prepared by direct condensation of isatin with hydrazine carbodithioic acid in DMF for one hour.
The strategy for the synthesis of 3-[(2-bromo(3-pyridyl))methyl]2-methylquinoline-4-carboxylic acid involves the use Pfitzinger reaction starting with suitably substituted isatin and 4-(2-bromo-3-pyridyl)butan-2-one, which was in turn synthesized which was in turn synthesized starting from 2-bromopicoline.
The reaction of isatin 1(1 mmol), hydrazine hydrate 2 (2 mmol) and ethyl acetoacetate 3 (2 mmol) was investigated as a model reaction.
6] Anku Patel, Sanjay bari, Gokul Talele, Jitendra Patel and Manda Sarangapani, Synthesis and Antimicrobial Activity of Some New Isatin Derivatives", Iranian Journal of Pharmaceutical research, (2006)4:249-254.
Many chemical compounds are found in IR, including indigotin, indirubin, isatin, isaindigotidione, organic acids, and amino acids (Wu et al.
De Clercq, Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New Bis- Schiff Bases of Isatin and their Derivatives, Pharm.