Isolated Organs

Isolated Organs

 

body parts, organs, or systems, separated from the body and placed in an artificial nutrient medium and temporarily retaining their principal functional properties.

Muscle, nerve, intestine, uterus, heart, extremity, head, and organs may be isolated. In physiology, isolated organs can be used to study certain aspects of organ activity; in pharmacology, to elucidate the action of medicinal substances and poisons. Complete isolation from the central nervous system makes possible the investigation of mechanisms of local regulation. Thus, it was established on an isolated heart that the character and intensity of heart contractions depend not only on the influence of the central nervous system and the effect of humoral factors but also on the degree of expansion of the fibers of the heart muscle and regulation by intracardiac neural formations. Comparatively simple conditions are required to preserve the viability of the isolated organs of cold-blooded animals. Thus, to maintain the functional capacity of a neuromuscular preparation from a frog for several hours it is necessary only to prevent it from drying out by moistening it periodically with normal saline. Isolating organs of warm-blooded animals is considerably more difficult: immediately after separation from the body it is necessary to provide for the delivery of nutritive substances and oxygen and the removal of metabolic products and to maintain the temperature at 37°-38°C. Isolation of the brain or head presents an especially difficult problem. Isolated organs taken from a donor or corpse are also used in transplants.

G. I. KOSITSKII and I. N. D’IAKONOVA

References in periodicals archive ?
Realization of tightness tests of pregnant isolated organs - period from 01.
They have not been modified to date and represent the dose limitation levels for isolated organs.
The LifeSustainer(TM) 1000 can simultaneously perfuse two isolated organs while monitoring their viability and function.
The LifeSustainer(TM) 1000 is designed to be used by biomedical researchers for studying the metabolism and function of isolated organs for use in drug discovery and other related research.
When the 52-week study concluded, the lupus patients who were treated with BENLYSTA had improvement in overall disease activity without clinically significant flare-ups in one or more isolated organs when compared to patients who received the placebo (inactive agent).
cancer) or isolated organs, all highly artificial model systems which are often not compatible with survival imaging.
Such devices are used in biomedical research, to preserve human organs for transplant and for therapeutic treatment of isolated organs.
UTHealth School of Dentistry wishes to purchase (not lease) plastinated human cadaver specimens including brains, half and whole heads and necks, isolated organs, thoracic and abdominal organs in natural relationship to each other, a torso with internal organs partially dissected, and heads sectioned horizontally, frontally and sagittally.
The company also provides organ preservation and perfusion research services on a contact basis to pharmaceutical and biotechnology companies interested in using isolated organs for drug discovery and other types of biomedical research.
Such devices are used in biomedical research, to preserve human organs for transplants and for therapeutic treatment of isolated organs.
The company also intends to provide organ preservation and perfusion research services to pharmaceutical and biotechnology companies as well as non-profit research institutions interested in using isolated organs for drug discovery and other types of biomedical research.

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