Six reversed C-glycopeptidomimetics were prepared using Passerini reaction; a three components reaction of aldehyde, carboxylic acid and isonitrile to furnish amide ester linkage Scheme-1.
Passerini reaction was carried out at room temperature using sugar aldehyde 1b, different aliphatic acids (2a-2f) and isonitrile 3c in dichloromethane and stirred for 8 hours to overnight (vide experimental).
Biosynthesis of the novel diterpene isonitrile diiso-cyanoadociane by a marine sponge of the Amphimedon genus: incorporation studies with sodium (2-[.sup.14.C]) cyanide and sodium ([.sup.14.C]) acetate.
Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges.
The resulting isonitriles
contained chemical groups called esters, which typically produce fruity and flowery smells.