, Myocardial infarction, Frankincense, I3-irradiation, Cardiac marker enzymes.
In some studies with hiPSC-CMs, the effects of isoprenaline
(changes in beating frequency and APD) were checked and responses similar to those in native cardiomyocytes were shown .
Calcium gluconate and isoprenaline
were infused and the blood pressure, after settling at 80/60, gradually rose, at first to a systolic of 90 mm.Hg, then 95 mm.Hg and finally 110 mm.Hg.
Antioxidant effect of Garcinia indica fruit extract against isoprenaline
hydrochloride induced myocardial necrosis in rats.
Normal: normal control; ISO: model group only injected with isoprenaline
; POS: positive control (propranolol, 10mg/kg); Diosgenin L, Diosgenin M, and Diosgenin H: orally given diosgenin 20, 40, and 80 mg/kg of low, medium and high dose, respectively, after ISO injection; DN extract: orally given Dioscorea nipponica extract (500 mg/kg), after ISO injection.
[sz]-adrenoceptors ([sz]-ARs), comprising [sz]1, [sz]2, and [sz]3 subtypes, have been reported to play a critical regulatory role in blood vessel endothelial cells.[sup] [sz]-AR stimulation can promote angiogenesis by inducing the expression of vascular endothelial growth factor (VEGF), a crucial angiogenic protein.[sup] Isoprenaline
(ISO; a synthetic catecholamine and [sz]-adrenergic agonist) has been shown to increase VEGF-A expression and VEGF receptor-2 (VEGFR-2) activity in hemangioma-derived endothelial cells.[sup] Similarly, ISO promotes angiogenesis in Matrigel cultures of human umbilical vein endothelial cells (HUVECs);[sup] however, the underlying mechanism remains to be clarified.
On rats, atria contraction was evaluated by screening the effects of isoprenaline
, acetylcholine, propranolol and atropine.
All the studies were done on adult male rats weighing between 200-340 grams and experimental model of heart failure was created either by ligation of the coronary artery or was induced by isoprenaline
inhibitory CRCs: The relaxant graphs for isoprenaline
were built against carbachol-induced contractions in trachea of guinea-pig in the lack and existence of the extract.
A well known example is that of bronchodilator isoprenaline
(isoproterenol) in which 3-OH group replacement with other bioisosteric group like 3-CH 2 OH, resulting salbutamol (albuterol), selective Beta-2 agonist, a well known antiasthamatic drug, by 3-NHSO 2 CH 3 , resulting soterenol and by 3-NHCONH 2 , resulting carbuterol [42-43].
However, acute treatment with the anticholinergic agent atropine and the adrenergic agonist isoprenaline
(Iso) may be warranted.
The relaxant effects of isoprenaline
are impaired in tracheal smooth muscle isolated from B.