Isoprenoids


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Isoprenoids

 

a large class of natural compounds formed in organisms from mevalonic acid. The latter is converted in the microsomes of the cells into “five-carbon fragments” with an isoprene skeleton. The biosynthesis of isoprenoids is a process of consecutive linking (condensation) of such five-carbon units into chains of various lengths. The doubling, cyclization, oxidation, reduction, and regrouping of such chains accounts for the extraordinary structural diversity of isoprenoids. The isoprenoids include terpenes and their derivatives, sterols, steroids, carote-noids, xanthophylls, and the polyisoprenoids—natural rubber and gutta-percha. A number of isoprenoids have great biological significance—many hormones of animals, plants, and lower organisms; certain vitamins; antibiotics; and attractants.

REFERENCES

Biosintez lipidov. Moscow, 1962.
Kosover, E. Molekuliarnaia biokhimiia. Moscow, 1964. (Translated from English.)
Biokhimiia rastenii. Moscow, 1968. (Translated from English.)
References in periodicals archive ?
The major isoprenoid alkanes in the analysed samples are pristane (Pr) and phytane (Ph) (Fig.
The first target molecules are part of the isoprenoid family (including carotenoids) that may lead to the production of specialty ingredients, such as antioxidants and / or high-added value pigments, representing a market of hundreds of millions of dollars worldwide in applications such as cosmetics, food, feed and health.
Eucalyptus species are strong source of isoprenoid emission.
The rate of degradation of n-alkanes (nC10 to nC34) and isoprenoids from oily sludge and treated soils over an incubation period of 3 to 60 days.
The first is regulation by isoprenoids such as phytosterols on the cytosolic form of HMGS, and the second is regulation by fatty acid on the mitochondrial form of HMGS.
1997, Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol.
This may be partially explained by the fact that simvastatin can inhibit isoprenoids synthesis rather than inhibit cholesterol biosynthesis.
Distribution of the mevalonate and glyceraldehydes phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714.
com)-- Isoprenoids in living organisms range in function from pigments and fragrances to vitamins and precursors of sex hormones.
Many organisms, including the parasite that causes malaria, make a class of molecules called isoprenoids, which play multiple roles in keeping organisms healthy, whether plants, animals or bacteria.
DEINOCHEM's priority target is isoprenoids, which are one of the most diverse families of natural substances (over 22,000 isoprenoid compounds listed to date).
In: Cane (ed) Comprehensive natural products chemistry: isoprenoids.