5) Compounds having the structure noncondensable pyridine ring or a quinoline or isoquinoline
cycles without further condensation; lactams; other heterocyclic compounds only with nitrogen hetero (20.
Bioassay-guided fractionation of the methanol extract led to the isolation of several compounds, mainly isoquinoline
alkaloids of the benzophenanthridine-type (Luo et al.
vulgaris which indicated that the most important constituents of this plant are isoquinoline
alkaloids such as berbamine, palmatine and particularly berberine (10).
Berberine is an isoquinoline
alkaloid found in numerous herbs including Hydrastis canadensis, Berberis aquifolium (syn.
In addition, isoquinoline
, phenylpyridine, benzenedicarbonitriles and pyridinecarbonitriles can be considered as markers of 'black N' (BN) (Knicker 2007; Kaal et al.
Rackova L, Oblozinsky M, Kostalova D, Kettmann V and L Bezakova Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline
Berberine, the major active component in Coptis Chinesis, is an isoquinoline
derivative alkaloid that is widely used in the treatment of calf diarrhea (Liu et al.
99) The effects of Berberis species, and the isoquinoline
alkaloid berberine in particular, have demonstrated in vitro effects against respiratory pathogens such as S.
The early steps of the morphine biosynthesis pathway leading from the primary metabolite tyrosine via the general isoquinoline
pathway to the tetracyclic salutsridinol have been clarified both at the metabolite and the enzyme level .
Putative role of isoquinoline
alkaloids in alcoholism: A link to opiates.
Nickel(II) complexes based on combination of N-N ligands with 6,7-dimethoxy-1,2,3,4-tetrahydro isoquinoline
or 3,4-dimethoxy pheneth-ylamine of the formulas [Ni(phen)(6,7,THIQ) [([H.
Their topics include genetic and cellular multiple drug resistance in a diagnostic and therapeutic strategy in acute leukemia in children and adults, herb-drug interactions and implication in drug monitoring, bacteriophage therapies and enzybiotics as novel solutions to antibiotic resistance, nutrition and tuberculosis, reversing multidrug resistance by the isoquinoline
alkaloid glaucine, and finding the genetic solution for cancer in the mechanism of taxol cytotoxicity.