Isoquinoline


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isoquinoline

[¦ī·sə′kwin·ə‚lēn]
(organic chemistry)
C6H4CHNCHCH Colorless liquid boiling at 243°C; soluble in most organic solvents and dilute mineral acids, insoluble in water; derived from coal tar or made synthetically; used to make dyes, insecticides, pharmaceuticals, and rubber accelerators, and as a chemical intermediate.

Isoquinoline

 

colorless crystals with a faint odor of almonds. Melting point, 24.5°C, and boiling point, 243°C. Its structural formula is

Slightly soluble in cold water, isoquinoline dissolves readily in organic solvents. It is present in low concentration in coal tar, from which it is separated with quinoline. Isoquinoline is a stronger base than quinoline. The most important method of preparing isoquinoline and its derivatives is by cyclodehydration of /3-phenylethylamides of acids C6H5CH2CH2NHCOR (the Bischler-Napieralski reaction) followed by dehydrogenation of the resultant 3, 4-dihydroisoquinolines. The isoquinoline nucleus is present in a number of important alkaloids, such as papaverine, morphine, codeine, and curarine.

References in periodicals archive ?
Pyrolysis mechanisms of quinoline and isoquinoline with density functional theory.
In this way, a total of 23 isoquinoline were identified in our tentative to characterize the total alkaloid extract (Fig.
5) Compounds having the structure noncondensable pyridine ring or a quinoline or isoquinoline cycles without further condensation; lactams; other heterocyclic compounds only with nitrogen hetero (20.
The isoquinoline carboxamide PK11195, radiolabelled with tritium [3], carbon-11 [15], iodine-123/125 [16-18], and fluorine-18 [19] have been extensively used as pharmacological probes for studying the function and expression of the TSPO.
vulgaris which indicated that the most important constituents of this plant are isoquinoline alkaloids such as berbamine, palmatine and particularly berberine (10).
Berberine is an isoquinoline alkaloid found in numerous herbs including Hydrastis canadensis, Berberis aquifolium (syn.
In addition, isoquinoline, phenylpyridine, benzenedicarbonitriles and pyridinecarbonitriles can be considered as markers of 'black N' (BN) (Knicker 2007; Kaal et al.
Baser, "A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species," Life Sciences, vol.
Rackova L, Oblozinsky M, Kostalova D, Kettmann V and L Bezakova Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids.
in particular studied a variety of different alkaloid pathways, including those of the isoquinoline alkaloids (IQAs).
99) The effects of Berberis species, and the isoquinoline alkaloid berberine in particular, have demonstrated in vitro effects against respiratory pathogens such as S.