Isoquinoline

(redirected from Isoquinolines)
Also found in: Medical.

isoquinoline

[¦ī·sə′kwin·ə‚lēn]
(organic chemistry)
C6H4CHNCHCH Colorless liquid boiling at 243°C; soluble in most organic solvents and dilute mineral acids, insoluble in water; derived from coal tar or made synthetically; used to make dyes, insecticides, pharmaceuticals, and rubber accelerators, and as a chemical intermediate.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Isoquinoline

 

colorless crystals with a faint odor of almonds. Melting point, 24.5°C, and boiling point, 243°C. Its structural formula is

Slightly soluble in cold water, isoquinoline dissolves readily in organic solvents. It is present in low concentration in coal tar, from which it is separated with quinoline. Isoquinoline is a stronger base than quinoline. The most important method of preparing isoquinoline and its derivatives is by cyclodehydration of /3-phenylethylamides of acids C6H5CH2CH2NHCOR (the Bischler-Napieralski reaction) followed by dehydrogenation of the resultant 3, 4-dihydroisoquinolines. The isoquinoline nucleus is present in a number of important alkaloids, such as papaverine, morphine, codeine, and curarine.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
They found that, instead of MAO-B, it was mitochondrial CYP2D6 that activate the beta-carbolines and isoquinolines inside the dopamine-producing neurons, rather than the glial cells.
Isoquinoline alkaloids (ISQAs)--nitrogen containing secondary metabolites derived from the two amino acids phenylalanine and tyrosine--are the largest group of natural products.
Isoquinolines functionalized with fluorine and fluorine-containing groups, the focus of this review, are key pharmacores with many applications.
Dopaminergic isoquinoline alkaloids from roots of Xylopia papuana.
1) are isoquinolines alkaloids isolated from different species of Amaryllidaceae.
Caption: Figure 11: The main structures of phenanthrene and isoquinoline [21, 22].
The isoquinoline alkaloids are widely distributed in the realm of flora and fauna, and have gained significant consideration on account of their enormous biological activities [1].
Isoquinoline alkaloids, which currently number more than 2500 members, are isolated mainly from plants of subclasses Magnoliidae and Ranunculidae (Blaschek et al.
The alkaloid tetrandrine had also immunosuppressive effects and blocked T cell signaling [47, 48] and the isoquinoline alkaloid berberine was shown to block an inflammatory T cell response and the expression of costimulatory molecules by dendritic cells [49].
Presence of methyl-6,7dihydroxy-1,2,3,4-tetrahydroisoquinolines, derivatives of the neurotoxin isoquinoline, in parkinsonian lumbar CSF.