Isotonicity


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Isotonicity

 

relative constancy of osmotic pressure in the fluid media and tissues of the body, a result of the maintenance at a given level of the concentrations of electrolytes, proteins, and other substances.

Isotonicity is one of the body’s most important physiological constants, which are ensured by mechanisms of self-regulation. Deviation of osmotic pressure from the normal physiological level (≈76–0.81 meganewtons per sq m, or 7.6–8.1 atmospheres) leads to the disruption of metabolic processes between the blood and the interstitial fluid.

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To ensure thorough homogenization, the homogenate was subjected to two round of freeze-thaw and centrifuged at 1,000 g for 10 min at 4[degrees]C, the suspension was collected and pellet was homogenized again, then supernatants from each centrifugation-step were pooled and equal volume of 2xPBS was added to restore isotonicity.
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To estimate the construct validity, we used correlation analysis to check the isotonicity (Golany and Roll, 1985; Golany, 1988) among the inputs and outputs.
The resulting pellet of white ghosts was incubated in 10 mmol/L 6-methoxy-N-(3-sulfopropyl)quinolinium (SPQ; Molecular Probes, Eugene, Ore) for 5 min, and sufficient NaCl was added to restore isotonicity.