Expressions of cyclooxygenase-2 (Cox2), inducible nitric oxide synthase (iNOS), and Ox42 Itgam
were measured in the brain.
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM
, PXK, KIAA1542 and other loci.
EV origin Surface markers Endothelium [CD31.sup.+]/[CD41.sup.-]([PECAM.sup.+]/[ITGA2B.sup.-]) [CD31.sup.+]/[CD42.sup.-] ([PECAM.sup.+]/[GPIb.sup.-]) CD31 (PECAM (platelet cell adhesion molecule)) CD144 (VE cadherin (vascular endothelial cadherin)) CD146 (MCAM (melanoma cell adhesion molecule)) CD105 (endoglin) CD106 (VCAM (vascular cell adhesion molecule)) CD62E (E-selectin (endothelial-selectin)) Platelet CD41 (ITGA2B (integrin alpha 2b)) CD42 (GPIb (glycoprotein Ib)) CD31 (PECAM (platelet cell adhesion molecule)) Leukocyte CD45 (PTPRC (protein tyrosine phosphate receptor type C)) CD11b (ITGAM
(integrin alpha M)) CD14 (coreceptor of lipopolysaccharide) CD16 (on surface of neutrophils, monocytes, and macrophages) CD62L (L-selectin (leukocyte selectin)) Red blood cell CD235 (glycophorin A)
Prahalad et al., "Evaluation of genetic association between an ITGAM
non-synonymous SNP (rs1143679) and multiple autoimmune diseases," Autoimmunity Reviews, vol.
These genes include Ets-1 and FoxP3 ; ITGAM
and FcyRIIIA ; PD-1.3A, C4AQ0, and MBL ; AlFadhli (IRF9, ABCA1, APOBEC3, CEACAM3, OSCAR, TNFA1P6, MMP9, and SLC4A1) ; FCGR3A and FCGR3B ; Tlr7 ; TBX21 and IFNG ; CD95 and CCR7 ; Fkbp11 ; JHDM1D and HDAC1-3 ; IL-28RA ; andpSTAT1 and ETS1 .
This detailed study also includes the major drugs listed for glomerulonephritis that consist of (irbesartan + propagermanium), ACH-4471, AMY-101, AVX-002, BaxB-01, BaxG-03, belimumab, blisibimod, BLR-400, budesonide, CCX-140, corticotropin, eculizumab, fostamatinib disodium, iosmapimod, monoclonal antibodies to inhibit ITGAM
for cardiovascular, immunology and Kidney Diseases.
The concentration of TNF, IL10, ITGAM
, and IL1B was detected by ELISA in the hepatocyte homogenates, and the results showed that these inflammatory factors, especially TNF, IL10, and IL1B, were significantly elevated in the pSS group than the control (p = 0.0037, 0.0047, and 0.0161, Figure 3A).
Association of ITGAM
polymorphism with systemic lupus erythematosus: A meta-analysis.
Criswell et al., "Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM
, PXK, KIAA1542 and other loci," Nature Genetics, vol.