isoniazid

(redirected from Izoniazid)
Also found in: Dictionary, Thesaurus, Medical.

isoniazid

(ī'sōnī`əzĭd), drug used to treat tuberculosistuberculosis
(TB), contagious, wasting disease caused by any of several mycobacteria. The most common form of the disease is tuberculosis of the lungs (pulmonary consumption, or phthisis), but the intestines, bones and joints, the skin, and the genitourinary, lymphatic, and
..... Click the link for more information.
. Also known as isonicotinic acid hydrazide, isoniazid is the most effective antituberculosis drug currently available. The drug inhibits or kills the tubercle bacilli that cause the disease. It is usually given together with some other antituberculosis drug such as streptomycinstreptomycin
, antibiotic produced by soil bacteria of the genus Streptomyces and active against both gram-positive and gram-negative bacteria (see Gram's stain), including species resistant to other antibiotics, e.g.
..... Click the link for more information.
 or para-aminosalicylic acid to prevent emergence of drug resistant organisms (see drug resistancedrug resistance,
condition in which infecting bacteria can resist the destructive effects of drugs such as antibiotics and sulfa drugs. Drug resistance has become a serious public health problem, since many disease-causing bacteria are no longer susceptible to previously
..... Click the link for more information.
). To prevent development of tuberculosis in individuals who have a positive reaction to a tuberculin skin test, isoniazid is given alone. Side effects are seen only with very high doses.

isoniazid

[‚ī·sə′nī·ə·zəd]
(pharmacology)
C6H7N3O A drug used as a tuberculostatic. Also known as isonicotinic acid hydrazide.
References in periodicals archive ?
Hastaya izoniazid 10 mg/ kg/gun tek doz, rifampisin 10 mg/kg/gun tek doz baslandi.
PPD'si pozitif ve akciger grafisi normal olan hastalar ile anormal, ancak stabil grafi bulgulari olup, balgam kulturunde ureme olmayan hastalar, latent TBC infeksiyonu acisindan, 300 mg/gun izoniazid ile 9 ay boyunca profilaksi almalidirlar.
Tuberkuloz menenjit tedavisinde genellikle ilk iki ay izoniazid, rifampisin, pirazinamid ve streptomisinden olusan dortlu tedavi uygulanir ve daha sonra tedavi izoniazid ve rifampisin ile 12 aya tamamlanir.
Koruyucu tedavi biyolojik tedaviden 1 ay once baslamali ve bu amacla 9 ay 300 mg/gun izoniazid verilmelidir.
Of the patients, 81.8% were treated with izoniazid, rifampicin, pyrazinamid and streptomycine or ethambutole for two months initially, with izoniazid, rifampicin during the following 10 months.
Santral sinir sistemi tuberkulozu, milier tuberkuloz ve kemik eklem tuberkulozu disindaki tuberkuloz formlarinda onerilen tedavi baslangicta uc ilacla (izoniazid, rifampisin ve pirazinamid) iki ay yogun tedavi, daha sonra iki ilacla (izoniazid ve rifampisin) tedavinin alti aya tamamlanmasidir.