Jak-STAT pathway

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Jak-STAT pathway

[′jak‚stat ′path‚wā]
(cell and molecular biology)
A rapid signal transduction pathway used by a variety of cytokines and growth factors to alter gene expression. Binding of a cytokine or growth factor to its receptor activates Jak (janus kinase—a cytoplasmic tyrosine kinase) and triggers it to phosphorylate and stimulate STAT (signal transducers and activators of transcription—a gene regulatory protein) to travel to the nucleus and induce transcription of a specific gene.
References in periodicals archive ?
The inhibition of these enzymes helps interfere with the JAK-STAT signaling pathway, which has been found to play a key role in the development of various autoimmune disorders and cancer indications.
Differentially expressed JAK-STAT signaling pathway genes and target microRNAs in the spleen of necrotic enteritis-afflicted chicken lines.
Sheehan et al., "Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway," Cell, vol.
faecalis invasion, namely, "Wnt signaling pathway," "Jak-STAT signaling pathway," "MAPK signaling pathway," "mTOR signaling pathway," "focal adhesion," "regulation of actin cytoskeleton," "adherens junction," "pathogenic Escherichia coli infection," "T cell receptor signaling pathway," "B cell receptor signaling pathway," "Toll-like receptor signaling pathway," "apoptosis," and "p53 signaling pathway" (Table 2).
KEGG pathway analysis suggested that positive-related genes of SNHG3 were mainly enriched in Notch signaling pathway, p53 signaling pathway, and GnRH signaling pathway, and negative-related genes of SNHG3 were mainly enriched in Jak-STAT signaling pathway, Toll-like receptor signaling pathway, MAPK signaling pathway, calcium signaling pathway, Wnt signaling pathway, and ErbB signaling pathway (Figures 3(c) and 3(d)).
Research indicates that inhibiting the JAK-STAT signaling pathway induces anagen and subsequent hair growth, but activating STAT 5 in the dermal papilla is also important to induce the growth phase of the hair follicle, according to Dr.
The oar-miR-26a was related to the functions of reentry into the mitotic cell cycle, leukocyte mediated immunity, gap junction channel activity, and the signaling pathways of Lysosome, Jak-STAT signaling pathway, and adrenergic signaling in cardiomyocytes.
In Drosophila, the JAK-STAT signaling pathway, whose functions overlap with those of the Hh signaling pathway, enhances the proliferation of SSCs and the overexpression of the antiapoptosis protein DIAPI in cells, which helps sustain the activity of SSCs [70].
KEGG signaling pathways P value KEGG_04115: p53 signaling pathway 2.24E - 10 KEGG_04310: Wnt signaling pathway 4.83E - 09 KEGG_04330: notch signaling pathway 1.34E - 06 KEGG_04630: Jak-STAT signaling pathway 3.83E - 04 KEGG_04722: neurotrophin signaling pathway 1.73E - 03 KEGG_04340: hedgehog signaling pathway 1.89E - 03 KEGG_04010: MAPK signaling pathway 3.33E - 03 KEGG_04370: VEGF signaling pathway 4.06E - 03 KEGG_04350: TGF-beta signaling pathway 4.98E - 03 KEGG_04660: T cell receptor signaling pathway 9.59E - 03 KEGG_04150: mTOR signaling pathway 2.14E - 02 KEGG_04920: adipocytokine signaling pathway 3.27E - 02 KEGG_03320: PPAR signaling pathway 3.36E - 02
Further, the JAK-STAT signaling pathway is negatively regulated by the suppressor of cytokine signaling (SOCS) proteins [3, 4].
On the other hand, SOX2 regulates the expression of STAT3 through JAK-STAT signaling pathway. [sup][46] In mouse embryonic fibroblast cells, n-butylidenephthalide triggers the up-regulation of SOX2 and OCT4 gene expression levels.
The JAK-STAT signaling pathway transmits information from chemical signals outside the cell, through the cell membrane, and into gene promoters on the DNA in the cell nucleus, which causes DNA transcription and activity in the cell (4).