To control the
Jak-STAT pathway activation, three main negative feedback mechanisms have been proposed.
The IFNAR-1 significance can be observed from a study where restored IFNAR-1 expression alone was able to restore defective
JAK-STAT pathway, STAT-1 and STAT-3 phosphorylation and anti-HCV response in IFN- resistant cell lines.
The binding of IL-31 to its receptors activates powerful signalling pathways (i.e., the activation of Janus kinase JAK1 and JAK2 and the start of
JAK-STAT pathway) [24,25].
Another proinflammatory cytokine, IL-1[beta], is involved in the pathogenesis of the neuropathic pain component of RA regulated by the
JAK-STAT pathway [39-41].
Kobori, "Interferon-[gamma] biphasically regulates angiotensinogen expression via a
JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells," The FASEB Journal, vol.
The results could mean "that inhibition of the
JAK-STAT pathway may be a new therapeutic target for AD," wrote the study's lead author, Robert Bissonnette, MD, president of Innovaderm Research in Montreal (Br J Dermatol.
It is well known that the
Jak-STAT pathway can regulate cell growth, apoptosis, immunity, and inflammatory responses and because of its significance in the immune response, the
Jak-STAT pathway is often exploited by pathogens [45].
When IL-12 is a ligand for the
JAK-STAT pathway in macrophages, a proinflammatory response of Th1 is produced, but when IL-10 is present, IL-12's proinflammatory effects are downregulated (Figure 1).
Activation of the
JAK-STAT pathway has also been demonstrated to confer cardioprotection in both in vitro and in vivo IR models and be involved in the early-phase and late-phase protection induced by IPC [21-23].
However, it is still not known whether DJC acts via the
JAK-STAT pathway. In this study, we hypothesized that DJC may improve renal function via a mechanism that involves
JAK-STAT pathway activation and antioxidant activity.
Progression of liver disease can be controlled by a number of cellular mediators among which
JAK-STAT pathway plays a significant role.