Jak-STAT pathway

Jak-STAT pathway

[′jak‚stat ′path‚wā]
(cell and molecular biology)
A rapid signal transduction pathway used by a variety of cytokines and growth factors to alter gene expression. Binding of a cytokine or growth factor to its receptor activates Jak (janus kinase—a cytoplasmic tyrosine kinase) and triggers it to phosphorylate and stimulate STAT (signal transducers and activators of transcription—a gene regulatory protein) to travel to the nucleus and induce transcription of a specific gene.
References in periodicals archive ?
To control the Jak-STAT pathway activation, three main negative feedback mechanisms have been proposed.
The IFNAR-1 significance can be observed from a study where restored IFNAR-1 expression alone was able to restore defective JAK-STAT pathway, STAT-1 and STAT-3 phosphorylation and anti-HCV response in IFN- resistant cell lines.
The binding of IL-31 to its receptors activates powerful signalling pathways (i.e., the activation of Janus kinase JAK1 and JAK2 and the start of JAK-STAT pathway) [24,25].
Another proinflammatory cytokine, IL-1[beta], is involved in the pathogenesis of the neuropathic pain component of RA regulated by the JAK-STAT pathway [39-41].
Kobori, "Interferon-[gamma] biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells," The FASEB Journal, vol.
The results could mean "that inhibition of the JAK-STAT pathway may be a new therapeutic target for AD," wrote the study's lead author, Robert Bissonnette, MD, president of Innovaderm Research in Montreal (Br J Dermatol.
It is well known that the Jak-STAT pathway can regulate cell growth, apoptosis, immunity, and inflammatory responses and because of its significance in the immune response, the Jak-STAT pathway is often exploited by pathogens [45].
When IL-12 is a ligand for the JAK-STAT pathway in macrophages, a proinflammatory response of Th1 is produced, but when IL-10 is present, IL-12's proinflammatory effects are downregulated (Figure 1).
Activation of the JAK-STAT pathway has also been demonstrated to confer cardioprotection in both in vitro and in vivo IR models and be involved in the early-phase and late-phase protection induced by IPC [21-23].
However, it is still not known whether DJC acts via the JAK-STAT pathway. In this study, we hypothesized that DJC may improve renal function via a mechanism that involves JAK-STAT pathway activation and antioxidant activity.
Progression of liver disease can be controlled by a number of cellular mediators among which JAK-STAT pathway plays a significant role.
Several of these newly discovered mutations raise the possibility of targeting subpopulations of JMML cases with existing drugs: Janus kinase (JAK) inhibitors, currently used to treat certain other bone marrow and blood cancers such as polycythemia vera, might inhibit signaling through a hyperactive JAK-STAT pathway identified in some patients, while other agents such as 5-azacytidine, most commonly used as a treatment for a blood disorder known as myelodysplastic syndrome, could be used to reduce excessive epigenetic DNA methylation seen in others.