Amyloidosis

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amyloidosis

[‚am·ə·loi′dō·səs]
(medicine)
Deposition of amyloid in one or more organs of the body.

Amyloidosis

 

or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.

V. V. SEROV

References in periodicals archive ?
Family flowers only, donations in lieu to the National Osteoporosis Society, c/o John Abercrombie, Funeral Director, 6 Holmlea, Crookham Village, Cornhill-on-Tweed, TD12 4SY.
Two goals from Cathays United's John Abercrombie was not enough to stop Cathays Park Rangers getting their first point in a 2-2 draw.
Burston and John Abercrombie for their help and excellence during this sad time.
His career has seen him perform and record with artistes including Art Farmer, Freddie Hubbard, Eddie Henderson, Joe Zawinul, Gary Bartz, Carter Jefferson, Vince Mednoza, John Abercrombie, Hamiet Bluiett, Idris Muhammad, Ronnie Burrage, Harvie Swartz, Mike Stern, Jack Wilkins, Zbigniew Seifert, Cameron Brown, Andy McKee, Greg Brandy, David Gilmore and Dave Friedman.
In the band are the Brecker Brothers and John Abercrombie among others.
Featuring Larry Coryell, Badi Assad, and John Abercrombie.
Starring: Nancy Wilson, Max Roach Quartet, Medeski Martin & Wood, David Benoit, Charles Lloyd Quartet featuring John Abercrombie and Larry Grenadier, Keb' Mo', Carnegie Hall Jazz Band with John Faddis and Michael Brecker, Juan de Marcos' Afro-Cuban All Stars, Banu Gibson & the New Orleans Hot Jazz, and the Washington Preparatory High School Jazz Ensemble (Saturday); Wayne Shorter Quartet featuring Brian Blade, John Patitucci and Danilo Perez, Isaac Hayes, David Sanborn, Ozomatli, Femi Anikulapo-Kuti & Positive Force, Roy Hargrove, Keely Smith with Frank Capp's Juggernaut, ``the Cos of Good Music'' featuring Benny Green, Joe Lovano, Ralph Moore and others, Stefon Harris Quartet, and Toshi Reagon (Sunday).
Solo passages by all four players were outstanding and guitarist John Abercrombie decorated the ensembles with pretty obligato.
Bob Burston for his caring service and John Abercrombie for the funeral arrangements.
On target for the Saints were Warren Jones, John Abercrombie and Ashley Bryan with Piotr Marec, Ben Burke and Stephen Quinn replying for Brecon.
Larry Coryell, Badi Assad, John Abercrombie - Three Guitars (Chesky JD248)
The musicians backing Lloyd include two-thirds of the Brad Mehldau Trio (Mehldau on piano and Larry Grenadier on bass), guitarist John Abercrombie, and Higgins on drums and percussion.