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Deposition of amyloid in one or more organs of the body.



or amyloid dystrophy, a disorder of protein metabolism accompanied by the formation within tissues of a specific protein polysaccharide complex known as amyloid. The progress of the disease is associated with distortion of the protein-synthesizing function of the reticuloendothelial system and with accumulation of anomalous proteins in the blood plasma which act as autoantigens and also stimulate the formation of autoantibodies. As a result of antigen-antibody interaction, there is deposition of widely dispersed proteins which figure in the formation of amyloid. Once deposited in tissues, such as vascular and gland walls, the amyloid displaces functionally specialized elements of the organ; this process leads to the destruction of the organ.

Several types of amyloidosis are recognized: primary, secondary, and senile amyloidosis; amyloidosis with multiple myeloma; and localized tumorlike amyloidosis. Primary amyloidosis has no connection with any other disease; it affects mainly the cardiovascular system, alimentary tract, muscles, and skin. Secondary amyloidosis develops subsequent to other diseases which are accompanied by prolonged suppuration and tissue breakdown, such as tuberculosis, syphilis, and rheumatoid arthritis. It most often affects the spleen, liver, kidneys, adrenal glands, and intestines. Senile amyloidosis usually involves the heart. Amyloidosis may be either general or localized. Im-munodepressive and hepatic preparations are used in its treatment.


References in periodicals archive ?
But there's no way that John Abercrombie is resting on his laurels.
Berwick Branch), c/o John Abercrombie, Funeral Director, Holmlea, Crookham, Cornhill-on-Tweed, TD12 4SY.
Dave Herbert for his comforting service and all who attended Crookham Church and Cornhill, also, John Abercrombie for his exemplary professional arrangements.
RALPH TOWNER Anthem (ECM): Towner has a fine history of group work, from writing and singing the wonderful Silence Of A Candle with The Winter Consort and later Oregon back in the 70s, to various ECM albums with fellow guitarist John Abercrombie and saxophonist Jan Garbarek.
Family flowers only, donations in lieu may be given to The Great North Air Ambulance Fund c/o John Abercrombie, Funeral Directors, Holmlea, Crookham, Cornhill, TD12 4SY.
Johnson performed with his Bass Desires in the late-1980s (joined by Bill Frisell, John Scofield and Peter Erskine), and has also played regularly with John Abercrombie.
Smith for his comforting service and to John Abercrombie for excellent funeral arrangements.
The family of the late Allan would like to thank all relatives, friends and neighbours for their support and kindness, cards and floral tributes following their sad loss, the Reverend Keith Osborne for his comforting service, also to all at service who donated so generously the sum of PS572 to (Pancreatic Cancer Research), also to John Abercrombie and staff for excellent funeral arrangements.
Our special thanks must go to the Paramedics from Cheviot Primary Care Centre Wooler, where donations were sent and John Abercrombie.
With the ever-creative, even subversive Mark Feldman on violin, Marc Johnson on bass and probing drummer Joey Baron all in attendance, guitarist John Abercrombie moved from swing to chamber jazz, and from country/bluegrass to Hendrix in the space of an hour set.
The family of the late Peggy, wish to thank all family, friends and neighbours for sympathies expressed during their sad loss, thanks to John Abercrombie and the Rev.