Multiple abnormalities have been elucidated in junctional complexes
of cancerous tissues [19, 20].
At higher magnification, the plasma membrane of these cells possessed abundant microvillar projections with junctional complexes
joining adjacent cells (Figure 4(d)).
TJs and AJs, two pivotal junctional complexes
physically located in the ECs, are considered as the main structural components of the barriers.
The basal plasmalemma showed tight junctional complexes
with adjacent cell membrane and in certain areas distinct intercellular canaliculi were present between the cells.
Furthermore, the mechanisms that affect adhesion molecules and junctional complexes
and their significance in primary sclerosing cholangitis and extrahepatic cholestasis are elucidated.
With his collaborators, Palade described a transport system across the endothelium and identified the so-called Weibel-Palade bodies which play a role in coagulation and inflammation; he also described the neuronal synapses, the tight junctions and junctional complexes
in glomerular cells and the secretory pathways of proteins from the endoplasmic reticulum towards the extracellular compartment.
The junctional complexes
between follicular cells in the apico-lateral borders were quite distinct with a prominent tight jun ction from which single cilium sometimes projected from it into the luminal colloid (Fig.1D).
Several junctional complexes
, including adherens junctions and tight junctions, participate in this process .
Electron microscopy has demonstrated intracellular granules (presumably autophagosomes), poorly formed junctional complexes
, and occasional long processes with contractile microfilaments.
Electron microscopy often shows the presence of junctional complexes
between tumor cells, with or without pericellular basal lamina and cytoplasmic skeins of intermediate filaments.
The upregulation of gap junctional complexes
may be regarded as a useful way of informing the chromaffine cells when cholinergic synaptic transmission is absent; they might just as well be nonfunctional for various reasons.