Kallikreins


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Related to Kallikreins: Tissue kallikreins

Kallikreins

 

enzymes of blood plasma and the tissues of certain organs (kidney, pancreas, salivary glands, intestinal walls) that catalyze a reaction in which the quinines bradykinin and kallidin split off from the inactive protein precursor quinino-gen.

Kallikreins are enzymes of the trypsin type. They have ex-tremely narrow specificity and manifest biological activity char-acteristic of the quinines. A preparation of kallikreins from swinepancreas is used as a vasodilator, especially in disorders of peri-pheral blood circulation.

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The team has completed a series of drug screening activities which have led to the identification of some very promising novel kallikrein inhibitors.
As an important element of the kallikrein/kinin system (KKS), tissue kallikrein can cleave low-molecule kininogen into kinins (e.g., bradykinin and kallidin).
Kallikreins, a family of secreted serine proteases, have been identified as diagnostic and biomarkers for various malignancies.
Luo et al., "Human tissue kallikreins: from gene structure to function and clinical applications," Advances in Clinical Chemistry, vol.
Yousef a postdoctoral scientist at the Toronto Kallikrein Laboratory.
Blood biomarker levels to aid discovery of cancer-related single nucleotide polymorphisms: kallikreins and prostate cancer.
Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.
The kallikrein (KLK) [4] family of serine proteases is a putative source of such cancer biomarkers (1, 2).
Kallikreins and proteinase-mediated signaling: proteinase-activated receptors (PARs) and the pathophysiology of inflammatory diseases and cancer.
A proteolytic cascade of kallikreins in the stratum corneum.
His main research interests are tumor markers, especially a group of enzymes called human tissue kallikreins. His most recent research focuses on proteomic methodologies for identifying novel cancer biomarkers and the physiology of kallikrein enzymes, as they relate to cancer initiation and progression.