Kallikreins


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Related to Kallikreins: Tissue kallikreins

Kallikreins

 

enzymes of blood plasma and the tissues of certain organs (kidney, pancreas, salivary glands, intestinal walls) that catalyze a reaction in which the quinines bradykinin and kallidin split off from the inactive protein precursor quinino-gen.

Kallikreins are enzymes of the trypsin type. They have ex-tremely narrow specificity and manifest biological activity char-acteristic of the quinines. A preparation of kallikreins from swinepancreas is used as a vasodilator, especially in disorders of peri-pheral blood circulation.

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The team has completed a series of drug screening activities which have led to the identification of some very promising novel kallikrein inhibitors.
89,90) Kallikreins have several physiological roles, including regulating cancer cell growth, angiogenesis, invasion, and metastasis.
Yousef a postdoctoral scientist at the Toronto Kallikrein Laboratory.
Blood biomarker levels to aid discovery of cancer-related single nucleotide polymorphisms: kallikreins and prostate cancer.
Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.
The association with age, human tissue kallikreins 6 and 10 and hemostatic markers for survival outcome from epithelial ovarian cancer.
Coordinated steroid hormone-dependent and independent expression of multiple kallikreins in breast cancer cell lines.
Paul Baehr, President, CEO and Chairman of IBEX commented at the annual meeting, "Our long-term strategy is to build a therapeutic pipeline initially based on our proprietary cancer kallikreins.
A proteolytic cascade of kallikreins in the stratum corneum.
These evaluations have led to the commencement of licensing negotiations regarding the incorporation of kallikreins into clinical diagnostic tests.
His main research interests are tumor markers, especially a group of enzymes called human tissue kallikreins.
Two kallikreins (hK5 and hK6) were present at lower concentrations in CaP, whereas hK11 was present at increased concentrations.