Kallikreins


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Related to Kallikreins: Tissue kallikreins

Kallikreins

 

enzymes of blood plasma and the tissues of certain organs (kidney, pancreas, salivary glands, intestinal walls) that catalyze a reaction in which the quinines bradykinin and kallidin split off from the inactive protein precursor quinino-gen.

Kallikreins are enzymes of the trypsin type. They have ex-tremely narrow specificity and manifest biological activity char-acteristic of the quinines. A preparation of kallikreins from swinepancreas is used as a vasodilator, especially in disorders of peri-pheral blood circulation.

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The team has completed a series of drug screening activities which have led to the identification of some very promising novel kallikrein inhibitors.
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Yousef a postdoctoral scientist at the Toronto Kallikrein Laboratory.
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Genetic variation in KLK2 and KLK3 is associated with concentrations of hK2 and PSA in serum and seminal plasma in young men
Blood biomarker levels to aid discovery of cancer-related single-nucleotide polymorphisms: kallikreins and prostate cancer.
Very low PSA concentrations and deletions of the KLK3 gene
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A proteolytic cascade of kallikreins in the stratum corneum.
Distribution of 15 human kallikreins in tissues and biological fluids
These evaluations have led to the commencement of licensing negotiations regarding the incorporation of kallikreins into clinical diagnostic tests.
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His main research interests are tumor markers, especially a group of enzymes called human tissue kallikreins.
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Two kallikreins (hK5 and hK6) were present at lower concentrations in CaP, whereas hK11 was present at increased concentrations.
Discovery of candidate tumor markers for prostate cancer via proteomic analysis of cell culture-conditioned medium

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