Kanamycin


Also found in: Dictionary, Thesaurus, Medical, Wikipedia.
Related to Kanamycin: chloramphenicol, Kanamycin sulfate

kanamycin

[‚kan·ə′mīs·ən]
(microbiology)
C18H36O11N4 A water-soluble, basic antibiotic produced by strains of Streptomyces kanamyceticus; the sulfate salt is effective in infections caused by gram-negative bacteria.

Kanamycin

 

(Kantrex, Resistomycin), an antibiotic of the amino glycoside group.

Kanamycin was first obtained from the actinomycete Strep-tomyces kanamyceticus in 1957. It is soluble in water, thermostable, and polybasic. Kanamycin is effective against most gram-negative and gram-positive bacteria and mycobacteria. It is ineffective against yeasts, fungi, enterococci, and bacteroids. Kanamycin sulfate solution is administered intramuscularly in the treatment of tuberculosis. Although kanamycin has a low level of toxicity, in large doses it produces side effects on the kidneys and acoustic nerves.

References in periodicals archive ?
Bean regenerants with kanamycin were selected during three to five weeks for stable transformation.
Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis.
tumefaciens strain GV3101 harboring pCAMBIA-1301-CsEXP10 was grown on Yeast Extract Peptone (YEP) medium supplemented with 50 mg L-1 kanamycin and 50 mg L-1 rifampicin on incubator shaker (28 +-1degC, 250 rpm) for 16 h.
The next most frequent resistance isolates were resistance to erythromycin, cefoxitin, clindamycin, ampicillin, amoxicillin, tetracycline, and kanamycin 2 (8.33%).
was found to be maximum sensitive (Table 3) for Ciprofloxacin (100%) followed by Norfloxacin (85.71%), Tobramycin (85.71%), Ceftriaxone (71.42%), Amikacin (71.42%), Amoxycillin (71.42%), Ampicillin (71.42%) and Enrofloxacin (57.14%) but less sensitive to Neomycin, Streptomycin, Chloramphenicol, Kanamycin, Cefoperazone and Cephalexin.
Resistance to the aminoglycosides was 6% to kanamycin and 0% to gentamicin.
LaPiana, "Pharmacokinetics of kanamycin following intramuscular administration," Journal of Pharmacokinetics and Biopharmaceutics, vol.
The recombinant clones were selected on LB agar containing ampicillin (75 [micro]g/ mL) and kanamycin (25 [micro]g/mL).
Future studies should use antimicrobial agents such as cephalosporins, fluoroquinolones, and trimethoprim, which are now more commonly in use over some of the redundant (oxytetracycline, chlortetracycline, and tetracycline) antimicrobials or ones that are no longer commonly used to treat clinical infections (kanamycin, chloramphenicol, and nalidixic acid) to better determine the pollution source.
As compared to standard antifungal disc kanamycin, these complexes showed minor activity against selected fungal strains at 50 u l.