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C18H36O11N4 A water-soluble, basic antibiotic produced by strains of Streptomyces kanamyceticus; the sulfate salt is effective in infections caused by gram-negative bacteria.



(Kantrex, Resistomycin), an antibiotic of the amino glycoside group.

Kanamycin was first obtained from the actinomycete Strep-tomyces kanamyceticus in 1957. It is soluble in water, thermostable, and polybasic. Kanamycin is effective against most gram-negative and gram-positive bacteria and mycobacteria. It is ineffective against yeasts, fungi, enterococci, and bacteroids. Kanamycin sulfate solution is administered intramuscularly in the treatment of tuberculosis. Although kanamycin has a low level of toxicity, in large doses it produces side effects on the kidneys and acoustic nerves.