Kaposi's sarcoma


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Kaposi's sarcoma

(käp`əshē', kəpō`sē), a usually fatal cancer that was considered rare until its appearance in AIDSAIDS
or acquired immunodeficiency syndrome,
fatal disease caused by a rapidly mutating retrovirus that attacks the immune system and leaves the victim vulnerable to infections, malignancies, and neurological disorders. It was first recognized as a disease in 1981.
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 patients. First described by an Austro-Hungarian physician, Moritz Kaposi, in 1872, it appears in three forms and is characterized by vascular skin tumors. Kaposi's sarcoma is endemic in Africa, where it is more aggressive, seen in children and young men, and accounts for 10% of malignancies in Congo (Kinshasa) and Uganda. A mild form of the disease is sometimes seen in elderly men of Mediterranean origin. The development of AIDS-related Kaposi's sarcoma has been linked to a virus of the herpes group. In the early 1980s it was seen in nearly 50% of AIDS patients, but the proportion has decreased since that time. In AIDS, Kaposi's presents as barely raised pink or red papules or plaques that become widely disseminated on the skin and in the gastrointestinal and respiratory tracts, where they may cause extensive bleeding. Treatment includes chemotherapy or surgical excision, cryosurgury (destruction by freezing), or electrodessication (destruction by heat). Local radiation therapy can also be effective. AIDS patients are treated with Vinblastine, an active, but weak, agent, which further lowers immunity.

Kaposi's sarcoma

[kə′pō·sēz sär′kōm·ə]
(medicine)
A multifocal malignant or benign neoplasm that occurs in the skin and sometimes in lymph nodes or viscera and is composed of primitive tissue that is involved in blood vessel formation.
References in periodicals archive ?
| Transplant-related Kaposi's sarcoma is a rare complication of an organ transplant.
Macroscopically Kaposi's sarcoma presents as irregular macules on the skin in its early stages and develops a papular or nodular appearance in the later stages.
AIDS-associated Kaposi's sarcoma is linked to advanced disease and high mortality in a primary care HIV programme in South Africa.
With further research, these findings could help guide efforts to develop drugs that could prevent KSHV infection and reduce the risk of Kaposi's sarcoma.
Kaposi's sarcoma (KS) is a multifocal angioproliferative neoplasm caused by infection with human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma (KS)--associated herpesvirus.
Schwartz, "Epdiemiolgoic aspects of American Kaposi's sarcoma," Journal of Surgical Oncology, vol.
Yuksel, "Kaposi's sarcoma developing in a HIV-negative Crohn's disease patient shortly after azathioprine and corticosteroid treatment," Journal of Crohn's and Colitis, vol.
Successful treatment of post-renal transplant Kaposi's sarcoma with paclitaxel.
The product has Medicines and Healthcare products Regulatory Agency approval to treat AIDS-related Kaposi's sarcoma.
and Canadian cohorts participating in the North American Cohort Collaboration on Research and Design to compare time trends in cancer incidence between 86,620 adults with HIV and 196,987 demographically similar control subjects without HIV These study participants were followed from 1996 to 2009 for the development of nine cancers: Kaposi's sarcoma, non-Hodgkin's lymphoma, lung cancer, anal cancer, colorectal cancer, liver cancer, oral cavity/pharyngeal cancer, Hodgkin's lymphoma, and melanoma.
[ClickPress, Wed Sep 09 2015] Global Markets Direct's, 'AIDS - Related Kaposi's Sarcoma - Pipeline Review, H2 2015', provides an overview of the AIDS - Related Kaposi's Sarcoma's therapeutic pipeline.
INTRODUCTION: Cancers such as Kaposi's sarcoma were among the initial clinical diagnosis that led to the recognition of Human Immunodeficiency Virus (HIV) infections in 1981.