Karyopyknosis


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Related to Karyopyknosis: pycnotic, caseous necrosis

Karyopyknosis

 

shrinkage of a cell nucleus; one of the stages of necrobiosis preceding karyorrhexis and karyolysis.

The karyopyknotic nucleus shrinks because of a loss of water.It stains more intensively with basic dyes than does the nucleus of a normally functioning cell, since the nucleic acid, which isresponsible for such staining, splits off from the nucleoproteins in the nucleus.

References in periodicals archive ?
Normal structure of renal glomeruli and tubules in the sham group is shown in A and B; protein casts (yellow arrows) and erythrocytes (green arrows) were found in renal tubule lumens of rats in the shock and shock+drainage + NaHS groups, as shown in C and I; tubular epithelial cells with necrosis (yellow arrows) and karyopyknosis (green arrows) were observed in the shock and shock+drainage + NaHS groups, as shown in D and J; nearly normal architecture of glomeruli and tubules in the shock+drainage and shock+drainage + PPG groups is shown in E, F, G, and H, plus mild edema of tubular epithelial cells (yellow arrows) in H.
Morphological studies further revealed that vitexin ameliorated neuronal damage from I/R, including cell swelling, karyopyknosis and disintegration of nucleoli.
In the present study, exposure of acute concentrations of copper sulphate (E-1), lead nitrate (E-2) and their combination (E-3) for 96 h caused karyopyknosis which is marked by irreversible condensation of chromatin in the karyopycknosis in E-3 group was followed by karyorrhexis marked by fragmentation of the nucleus in necrotic cells (Figs.
There were karyopyknosis, chromatin agglutination and apoptosis bodies under transmission electron microscope (TEM) and DNA ladder by ultra-violet spectroscopy (UV) when NCI-H460 cells were exposed to Ardipusilloside I at different concentrations.
Different forms of cell nuclear alterations including karyorrhexis, karyopyknosis, and karyolysis were observed after DAPI staining (blue).
These abnormalities included marked binucleation, anisokaryosis, karyolysis, karyorrhexis and karyopyknosis. Some pyknotic hepatocytes of rats exhibited clumping and condensation chromatin condensation in the periphery of the nuclei together with irregularity nuclear membranes.