Keloid


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keloid

[′kē‚lȯid]
(medicine)
A firm, elevated fibrous formation of tissue at the site of a scar.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Keloid

 

a tumor-like growth of the fibrous connective tissue of the skin.

The causes of keloid development are not clear. Certain persons have a predisposition to their development. A distinction is made between true (spontaneous) keloids, which develop on visibly unchanged skin, and false keloids, which develop at the site of a scar after trauma (mechanical, thermal, chemical) or purulent disease (a furuncle, for example). A true keloid is a slightly elevated formation (5–8 mm above the skin surface) of whitish or pinkish color and dense consistency, with a smooth, shiny surface. Keloids appear most often in young people in the area of the chest, neck, and pinnae; and more rarely, on the face and limbs. Growth takes place for several weeks or sometimes months, after which the dimensions of the keloid remain unchanged throughout the patient’s lifetime. Treatment consists of injections of hyaluronidase and vitreous body; administration of vitamins PP, B2, and C; electrophoresis of potassium iodide; paraffin therapy; and X-ray therapy.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Several treatment and prophylactic modalities including surgical excision, radiation, pressure therapy, cryotherapy, topical silicone gel, intralesional corticosteroid injections, interferons, fluorouracil, laser treatment, and many other medications have been used in the management of HS and keloids.5-13 The aim of our study was to determine the prophylactic efficacy of topical corticosteroid ointment as a non-invasive form of therapy for post-operative HS and keloids following Cesarean section.
However, during treatment, the keloid lesion in the sternal notch increased in size.
A clinical trial conducted with sixty patients of keloid attended in the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka for duration of January 2013 to August 2013.
Three refused participation and 04 were ineligible due to exclusion criteria (02 had uncontrolled DM and 02 had infected keloid).
One way of looking at a tattoo is that it's ink under the skin and that alone makes it a risk in getting blood-borne diseases like HIV and hepatitis, skin infections, and of course, keloids. Red dye for tattooing has especially been identified to cause allergic reaction resulting in an itchy rash.
This surgery was complicated by fibromatosis and keloid scar formation, ultimately leading to amputation of the small finger.
Key words: Cicatrix, Hypertrophic; Keloid; Models, Animal; Rabbit; Transforming Growth Factor Beta 1.
Study was conducted on 156 patients with keloid of age about 5 years and above.
In addition to that, the difficulty in clinical distinction between keloids and hypertrophic scars and the lack of histopathological confirmation decrease the validity of these studies.[sup][34] The absence in keloid histological confirmation might be explained by the near-zero rate of malignancies or dysplasias.[sup][35] Therefore, due to the limitations, there are no preferred treatments of keloids in specific sites.
The purpose of this study was to make an ideal rabbit ear keloid model.
The pathophysiology of keloid is still not fully elucidated yet, although changes in the expression of cytokines [4, 5], increase in fibroblast proliferation [6], and exacerbated collagen synthesis [7] have been described in the literature.