Keratinization


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Keratinization

 

the accumulation of keratins—a type of protein—in cells of the epithelial tissue in vertebrates and humans. Keratinization mainly occurs within the surface layers of the skin—the epidermis and all its derivatives (scales, bill, plumage, wool, hooves, horns, hair, and nails).

In humans the keratinized cells in the surface layers of the skin are converted into squamules, which form the cornified layer of the epidermis. This layer is highly elastic and conducts heat poorly, thus protecting the underlying layers of the skin from such harmful factors as physical injury, desiccation, and bacterial infection. Keratinization is most evident on the palms and soles, less so at flexures. (For disorders in the keratinization process, seeHYPERKERATOSIS.)

References in periodicals archive ?
However, it has greater apoptosis and lacks prominent abnormal keratinization in the lower layers.
Disorders of keratinization. In: Behrman RE, Kliegman RM, Jenson HB, (eds).
Porokeratosis is a specific disease characterized by abnormality of proliferation and keratinization of epidermal cells, this abnormality presented in the histological point of view as a coronoid lamella which is a packed, parakeratotic cells presented along the stratum corneum, and in addition to this specific feature, a thin layer or lacking of granular layer is an associated feature.
The majority of small tumors are well differentiated squamous cell carcinomas with keratinization, but poorly differentiated cancers do occur, especially in large tumors.
Nests of neoplastic squamous epithelium with keratinization.
This study aimed to reveal the morphometric differences between blind rats which live underground and rats which live under laboratory conditions with regard to the length, base width, keratinization thickness and microscopic papilla depth.
It identified 5 factors associated with self-medication which are female sex, duration of dermatologic disease more than one year before consultation, and having developed the following type of skin diseases: adnexal dermatoses, keratinization disorders, and fungal skin infections.
Our results suggest that keratinization and stemness are two of the most differentially affected processes dysregulated by the E6 PDZ-binding motif.
Calcipotriol, a synthetic derivative of 1,25, dihydroxy vitamin D3 has been used topically, it acts through vitamin D receptors present on keratinocytes and lymphocytes thus decreasing epidermal proliferation, abnormal keratinization, and angiogenesis.
The use of the SCTG for the root coverage in periodontal surgery is considered the golden pattern to the gingival recession treatment [9, 10] due to its characteristics of quick keratinization and adherence.
Primary pure SCC of the gallbladder is a locally invasive cancer characterized by prominent keratinization, in the form of keratin pearls, without evidence of malignant glandular transformation [1].