keratinocyte

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keratinocyte

[kə′rat·ən·ə‚sīt]
(histology)
A specialized epidermal cell that synthesizes keratin.
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Now, what structural aspects do keratinocytes have that make them excellent units of the epidermal layer of skin?
For example, prolactin has been shown to promote keratinocyte proliferation and differentiation, angiogenesis, and a The proinflammatory local cutaneous milieu marked by a T-cell-predominant infiltrate.
They focused on the cell types in the epidermis - comprised of keratinocytes and a few bottom-layer melanin-producing melanocytes - in order to understand their various roles in color determination.
First, the undifferentiated keratinocytes population is enriched to 90%.
As I mentioned in my presentation, epidermal keratinocytes do migrate into a wound site as a stratified epithelial sheet.
Upon stimulation, the inducible nitric oxide (NO) synthase contributes to RNS production by generating large amounts of NO for defense or signaling purposes [15], also in keratinocytes [16].
Our previous studies have already demonstrated that human keratinocytes can recognize T.
This may also facilitate the evaluation of the efficacy of the treatments for AK and field cancerization at cellular level of keratinocytes," they added.
Recently, the host laboratory made the surprising observation that fibroblast growth factor receptor (FGFR) signalling has a tumor-suppressive function in the epidermis, since loss of FGFR1 and FGFR2 in mouse keratinocytes resulted in the development of skin inflammation, followed by spontaneous formation of carcinomas.
We also investigated the ability of GCO to increase aquaglycerolporins-3 (AQP-3) mRNA expression in cultured keratinocytes and human skin explants.
From those cells, the team grew precursor cells to keratinocytes, a type of skin cell that forms hair follicles, which produce hair, and then blended the precursor cells with mouse cells that stimulate hair production.