ketoglutarate


Also found in: Medical.

ketoglutarate

[‚kēd·ə′glüd·ə‚rāt]
(organic chemistry)
A salt or ester of ketoglutaric acid.
References in periodicals archive ?
Anti-mitochondrial antibodies (AMA) directed against the E2 subunit of pyruvate dehydrogenase (PDH-E2) which is a member of the inner mitochondrial membrane-expressed oxoacid dehydrogenase complex, and ketoglutarate dehydrogenase are present in 95% of the patients3.
These patients have combined deficiency of BKCD, pyruvate and alpha ketoglutarate dehydrogenase complexes.
Acute L-arginine alpha ketoglutarate supplementation fails to improve muscular performance in resistance trained and untrained men.
The following methods were used: calcium: Arsenazo III dye method; uric acid: the uricase method; glucose: glucose oxidase method; aspartate aminotransferase (AST): aspartate plus the alpha ketoglutarate method; and creatine kinase (CK): the creatine phosphate method.
The glutamate gets acted upon by glutamate dehydrogenase to generate alpha ketoglutarate and ammonia.
2) can be used as a further coupled-enzyme to form glutamic acid from ketoglutarate and ammonia; the reaction requires NADH and can be monitored at 340 nm [4].
Ammonia is measured using alpha ketoglutarate catalyzed by glutamate dehydrogenase to yield glutamate with the oxidation of NADPH to NADP.
du Pont de Nemours and Company (Wilmington, DE) has patented four chimeric genes, a first encoding lysine-insensitive aspartokinase, which is operably linked to a plant chloroplast transit sequence, a second encoding lysine-insensitive dihydrodipicolinic acid synthase, which is operably linked to a plant chloroplast transit sequence, a third encoding a lysine-rich protein, and a fourth encoding a plant lysine ketoglutarate reductase, all operably linked to plant seed-specific regulatory sequences.
It contains our proprietary Matraxol Technology Arginine Alpha Ketoglutarate, Cinnulin PF and LeucoSelect OPC," Hohn adds.
Glutamate is an amino acid that is an excitatory neurotransmitter that also makes the relaxing neurotransmitter called GABA and is also involved in making alpha ketoglutarate, which supports energy production.
Glutamate is acted upon by glutamate dehydrogenase generating alpha ketoglutarate and ammonia.