Kinetoplast


Also found in: Dictionary, Medical, Wikipedia.
Related to Kinetoplast: Kinetoplastida

kinetoplast

[kə′ned·ə‚plast]
(cell and molecular biology)
A genetically autonomous, membrane-bound organelle associated with the basal body at the base of flagella in certain flagellates, such as the trypanosomes. Also known as parabasal body.

Kinetoplast

 

a cell organelle; the basal nodule of the cilia of infusoria.

The origin of the kinetoplast is associated with the centriole, an assumption supported by the similarity in ultrastructure of the two organelles. In addition to proteins, carbohydrates, and lipids, the kinetoplast contains DNA and RNA and is capable of the independent biosynthesis of protein and of self-reproduction. Kinetoplasts may give rise to cilia or trichocysts. The tendency to call all basal bodies kinetoplasts is incorrect.

References in periodicals archive ?
First detection of Leishmania major in peridomestic Phlebotomus papatasi from Isfahan province, Iran: comparison of nested PCR of nuclear ITS ribosomal DNA and semi-nested PCR of minicircle kinetoplast DNA.
The first evidence of the existence of kinetoplast came over a century ago after the discovery of a basophilic granule located near the base of trypanosome's flagellum.
Ray, "Localization of a type II DNA topoisomerase to two sites at the periphery of the kinetoplast DNA of Crithidia fasciculata," Cell, vol.
Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis.
The present study was designed to report the prevalenceof Trypanosoma brucei in blood samples of donkeys (n=283) collected from Dera Ghazi Khan District in Punjab (Pakistan) through PCR amplification of their maxicircle kinetoplast DNA (kDNA) during four seasons in 2013 and to demonstrate the effect of this parasite on complete blood count (CBC) and selected parameters of serum.
(4,18-22) The target DNAs for these studies have been kinetoplast DNA, rDNA (internal transcribed spacer [ITS]), repetitive nuclear DNA, mini-exon genes, and microsatellite DNA.
Kinetoplast protozoa are characterized by a single mitochondrion near the flagellum which contains DNA in a small compartment called a kinetoplast [2].
Most of the Excavata organisms (6 species, 3 from the genus Leishmania and 3 belonging to the genus Trypanosoma) belong to a subgroup of the Euglenozoa called the Kinetoplastea, which are characterised, so far, by the presence of a mass of DNA associated with their flagellar bases (kinetoplast) (Adl, et al., 2005).
In addition, ultrastructural analyses showed remarkable alterations in the morphology of the Golgi complex, kinetoplast, endoplasmic reticulum and plasma membrane of trypomastigotes, confirming a pattern consistent with necrotic cell death.
and Trypanosoma cruzi, and is characterized by the presence of a kinetoplast (Shapiro and Englund, 1995).