Kinetoplastida

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Kinetoplastida

An order of the class Zoomastigophorea in the phylum Protozoa, also known as Protomastigida, containing a heterogeneous group of colorless flagellates possessing one or two flagella in some stage of their life cycle. These small organisms (5-89 μm in length) typically have pliable bodies. Some species are holozoic and ingest solid particles, while others are saprozoic and obtain their nutrition by absorption.

There is disagreement on the division of the order into families. However, the five or more families can be divided into two general groups (see illustration). The first group contains simple organisms with no distinctive features save one or two flagella of equal or unequal length (includes the families Oikomonadidae, Amphimonadidae, Monadidae, and Bodonidae). The second group contains organisms which have an undulating membrane in addition to one or two flagella (includes Trypanosomatidae and Cryptobiidae). The most important family is the Trypanosomatidae, since it includes several species that infect humans and domestic animals with serious diseases, such as African sleeping sickness. See Cilia and flagella

Representative genera of families of order Kinetoplastidaenlarge picture
Representative genera of families of order Kinetoplastida

Kinetoplastida

[kə‚ned·ə′plas·tə·də]
(invertebrate zoology)
An order of colorless protozoans in the class Zoomastigophorea having pliable bodies and possessing one or two flagella in some stage of their life.
References in periodicals archive ?
A postgenomic view of the heat shock proteins in kinetoplastids.
Editing of kinetoplastid mitochondrial mRNAs by uridine addition and deletion generates conserved amino acid sequences and AUG initiation codons.
For example, in kinetoplastid protozoa, RNA editing by addition and deletion of literally hundreds of uridine residues creates initiation and termination codons, alters the structural features of transcripts, and creates over 90% of the amino-acid codons (5).
Cross-reactivity of antibodies in human infections by the kinetoplastid protozoa Trypanosoma cruzi, Leishmania chagasi and Leishmania (viannia) braziliensis.
The KINDReD consortium integrates five leading academic laboratories in Europe (Portugal, United Kingdom, and Switzerland), the USA (California) and South America (Brazil) with high throughput screening (HTS) facilities equally distributed between all three major kinetoplastid parasites.
First, a molecular ancient DNA (aDNA) analysis identified a specific 123-bp fragment of a conserved region of the minicircle molecule of the parasite's kinetoplastid mitochondrial DNA (4,5) which on direct sequencing showed a Leishmania-specific sequence compatible with L.
Additionally, it is also valid to study the putative mechanism(s), as for example, kinetoplastid topoisomerase (I and II) are potential targets based on their structural differences with human type I DNA topoisomerases, making the enzyme an attractive target for chemotherapeutic intervention (Capranico et al.
They cover comparative genomics and drug discovery in trypanosomatids, the practical applications of comparative kinetoplastid genomics, the relevance of host-genes in malaria, nicotine acetylcholine receptors as drug and chemical targets, finding novel sodium channel inhibitors with a gene-family based approach, applications in translational medicine and using the web to identify novel drug targets.
Kala-azar, or visceral leishmaniasis, is caused by the presence in the blood and some organs, such as liver, spleen, and bone marrow, of the parasitic kinetoplastid protoctist Leishmania donovani, which is transmitted by the bite of a sandfly Phlebotomus.
Phylogenetic place of kinetoplastid protozoa inferred from protein phylogenies of elongation factors 1alpha and 2.