Kupffer cell


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Kupffer cell

[′ku̇p·fər ‚sel]
(histology)
One of the fixed macrophages lining the hepatic sinusoids.
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In Kupffer cells isolated from the rat liver, an increase in the TNF-[alpha] levels after I/R were discovered to be 5 times greater than the increase of the TNF-[alpha] levels in the control group.
Release and modification of 3H, 14C-lipopolysaccharide by isolated rat Kupffer cells," Gastroenterology, vol.
In the second phase, after 8 h of CCl[.sub.4]administration oxidant induced activation of kupffer cells occur, with the release of proinflammatory cytokines like tumor TNF-[alpha], TGF-[beta] and IL-6.
Using the ADF mode, Sonazoid bubbles phagocytosed by Kupffer cells were destroyed, with a high MI of 1.0 [5].
Morphometric Observation: Kupffer cell hyperplasia was observed as an established sign of liver injury by various researchers in their studies of severe [9,11] and moderate [2] heat stress.
As evident in Figures 2 and 3, there were degenerative changes such as ballooning degeneration, Kupffer cell hyperplasia, single cell necrosis/drop out as well as foci of necrosis, sinusoidal compression, and disruption of liver cell plates in the liver of 5 days exposed animals.
Some of the highlights include the concept of Kupffer cell activation and the role of these cells in liver inflammation, oxidative stress--related injury, stellate cell activation, and liver fibrosis.
Problems such as Kupffer cell dysfunction, microcirculatory changes, ATP depletion, the generation of reactive oxygen species, and increased leukocyte adhesion resulting from the ischemia reperfusion period of the liver transplantation sometimes lead to graft failure or primary nonfunction of the liver.
Kupffer cell (KC) activation is critical in NASH and precedes the recruitment of other cells, therefore contributing to NASH progression [72].
Horuzsko, "The proinflammatory myeloid cell receptor TREM-1 controls Kupffer cell activation and development of hepatocellular carcinoma," Cancer Research, vol.
In the second step, CEA binds to heterogeneous nuclear RNA binding protein M4 (hnRNP M4), a Kupffer cell receptor protein [17, 22-23].