Kupffer cell

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Kupffer cell

[′ku̇p·fər ‚sel]
(histology)
One of the fixed macrophages lining the hepatic sinusoids.
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Mild-to-moderate small-droplet steatosis and Kupffer cell hyperplasia were also seen.
In Kupffer cells isolated from the rat liver, an increase in the TNF-[alpha] levels after I/R were discovered to be 5 times greater than the increase of the TNF-[alpha] levels in the control group.
We therefore chose a monocyte cell line and a Kupffer cell line to preliminarily assess the toxicity of the compound.
Aoyama et al., "Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice," Gastroenterology, vol.
Dedousis et al., "Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance," Diabetes, vol.
In this pathway, a key role is played by Kupffer cells. They contribute to endotoxin clearance [43] and to inflammatory response, through several TLRs located in their surface that, after being activated by LPS, are able to trigger a cascade of events, leading to the production of inflammatory cytokines, such as IL-1[beta] and TNF-[alpha] [44].
This study aimed to determine the role of CD68, CD 11b, and CXCR3, as markers of resident Kupffer cells and BDM, in the differentiation between HCV reinfection and ACR in the postliver transplant setting using immunohistochemistry.
D-GaIN inhibits mRNA, and protein synthesis in hepatocytes increased the sensitivity to TNF-alpha released from Kupffer cells, which activate signaling pathways leading to cellular death.
(5) The classic and non-classic types contain variable amounts of Kupffer cells. (6)
Lebensztejn, "The role of Kupffer cells in the morphogenesis of nonalcoholic steatohepatitis--ultrastructural findings.
The hematopoietic tissue of the liver and Kupffer cells also originate from the septum transversum mesenchyme (1, 2, 7, 11, 19).
(17) The formation of a metastatic tumor must also overcome the immune cells of the spleen, such as monocytes and Kupffer cells. (4) In the rare event that a tumor does seed, imaging modalities such as CT and CT/PET in conjunction with rising CEA levels offers superb diagnostic detection capability.