glutamic acid

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Related to L-Glutamic Acid: L-glutamine, L-serine

glutamic acid

(glo͞otăm`ĭk), organic compound, one of the 20 amino acidsamino acid
, any one of a class of simple organic compounds containing carbon, hydrogen, oxygen, nitrogen, and in certain cases sulfur. These compounds are the building blocks of proteins.
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 commonly found in animal proteins. Only the l-stereoisomer occurs in mammalian proteins. Like aspartic acidaspartic acid
, organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer participates in the biosynthesis of proteins.
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, glutamic acid has an acidic carboxyl group on its side chain which can serve as both an acceptor and a donor of ammonia, a compound toxic to the body. Once glutamic acid has coupled with ammonia, it is called glutamineglutamine
, organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer occurs in mammalian protein.
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 and can as such safely transport ammonia to the liver, where the ammonia is eventually converted to ureaurea
, organic compound that is the principal end product of nitrogen metabolism in most mammals. Urea was the first animal metabolite to be isolated in crystalline form; its crystallization was described in the early 18th cent.
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 for excretion by the kidneys. Free glutamic acid (that not incorporated into proteins) can also be converted reversibly to α-ketoglutaric acid, an intermediate in the Krebs cycle, and as such can be degraded to carbon dioxide and water, or transformed into sugars. The acidic side chain of glutamic acid confers one negative charge under most conditions to proteins in which this amino acid is found, thus increasing the water solubility of the protein. Monosodium glutamate (MSG), the monosodium salt of l-glutamic acid, is widely used as a condiment. The amino acid was isolated from wheat gluten in 1866 and chemically synthesized in 1890. It is not essential to the human diet, since it can be synthesized in the body from the common intermediate α-ketoglutaric acid.
The Columbia Electronic Encyclopedia™ Copyright © 2013, Columbia University Press. Licensed from Columbia University Press. All rights reserved.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Glutamic Acid


an amino acid, COOH—CH2—CH2— CH(NH2)—COOH. Water-soluble crystals. Melting point, 202° C. It is a component of proteins and of a number of important low-molecular-weight compounds (for example, glutathione and folic acid). The natural form is the D(+) isomer. Glutamic acid is a nonessential amino acid for animals. It is contained in large amounts in casein, gelatin, and gluten. Together with the corresponding γ-monoamide, glutamine, it comprises about one-third of the total free amino acids in blood plasma. The reaction glutamic acid + NH3 + ATP ⇌ glutamine + ADP + Pinorg. is catalyzed by the enzyme glutamine synthetase, which belongs to the lyase group. This reaction results in the binding of excess ammonia in animal and vegetable tissues. Thus, glutamine transports ammonia to the site of its detoxification (mostly in the kidneys and liver). Glutamine also serves as an amino-group reserve and is a component of proteins. The glutamine-glutamic-acid system plays a particularly important role in metabolism. Glutamic acid also takes part in other important metabolic processes, such as transamination (where, with as partic acid, it is an invariable participant), in oxidative deamination leading to the formation of α-ketoglutaric acid (which is involved in the tricarboxylic acid cycle), in decarboxylation leading to the formation of the important neurotropic agent γ-aminobutyric acid, and in many syntheses, including glutathione, glucose, and ornithine.

Glutamic acid is utilized in the food industry as a sodium salt for improving the taste and nutritional value of foods. It is used in medicine in tablets, powders, and pastes, as well as in solutions (for intravenous infusion) in the treatment of some mental and nervous diseases. The calcium and magnesium salts of glutamic acid are also prescribed.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

glutamic acid

[glü′tam·ik ′as·əd]
C5H9O4N A dicarboxylic amino acid of the α-ketoglutaric acid family occurring widely in proteins.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Foliar sprays of the sugarcane fermented broth containing 30% (w/v) of L-glutamic acid, has improved potato total yield in both seasons.
The control diet had higher nitrogen intake and retention than the treatments with 14.00% CP (T3) and 15.74% CP + 1.349% L-glutamic acid (T5).
Thin layer chromatography was employed for detecting L-glutamic acid in the culture medium and solvent system consisted of n-butanol: acetic acid: water (2:1:1).
Factors Name Units Low level (-1) High level (+1) X1 Soluble starch % w/w 0.5 1.0 X2 Maltose % w/w 0.5 1.0 X3 Glucose % w/w 0.5 1.0 X4 Copper sulphate % w/w 0.5 1.0 X5 Zinc sulphate % w/w 0.5 1.0 X6 L-asparatic acid % w/w 0.5 1.0 X7 L-glutamic acid % w/w 0.5 1.0 X8 L-Histidine % w/w 0.5 1.0 X9 Sodium Nitrate % w/w 0.5 1.0 X10 Ammonium chloride % w/w 0.5 1.0 X11 Ammonium nitrate % w/w 0.5 1.0 TABLE 2: Plackett-Burman experimental design for the evaluation of nutritional factors affecting neomycin production by Streptomycesfradiae NCIM 2418.
Kitamura, "Polymorphism in the crystallization of L-glutamic acid," Journal of Crystal Growth, vol.
Thus, constant rate of production of L-glutamic acid (6.8 mg/ml) was obtained experimentally up to sixteen subculture of Micrococcus glutamicus [AB.sub.100] studied before employed this strain into further optimization study using a maintenance medium composed of: glucose, 1.0%; peptone, 0.5%; beef extract, 0.3%; yeast extract, 0.1% and agar 4.0% (as solidifying agent).
L-Glutamic acid HC1, also an amino acid, is a fundamental component of glycosaminoglycan structure.
L-glutamic acid is a precursor to neurotransmitters, but the synthetic form, d-glutamic acid, may stimulate the nervous system in pathological ways.
L-Glutamic acid helps to improve the conduction of nerve impulses and Magnesium is important for nervous system function.
(n=3) Organic Substrate use(A) compound NI I L-Arginine 324 [+ or -] 2 564 [+ or -] 10 Citric acid 56 4 [+ or -] 6 1644 [+ or -] 15 D-Glucose 504 [+ or -] 3 2824 [+ or -] 44 L-Glutamic acid 504 [+ or -] 3 854 [+ or -] 7 [Alpha]-Ketoglutaric acid 634 [+ or -] 4 964 [+ or -] 6 Lactose 264 [+ or -] 2 2344 [+ or -] 23 DL-Malic acid 1074 [+ or -] 5 2314 [+ or -] 10 D-Mannose 444 [+ or -] 4 134 [+ or -] 16 L-Serine 46 [+ or -] 4 126 [+ or -] 5 Tartaric acid 44 [+ or -] 5 984 [+ or -] 10 Organic Ratio of substrate use (B) compound Mean 95% confid.