Carnosine

(redirected from L-carnosine)
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carnosine

[′kär·nə‚sēn]
(biochemistry)
C9H14N4O3 A colorless, crystalline dipeptide occurring in the muscle tissue of vertebrates.

Carnosine

 

C9H14O3N4, a dipeptide (/3-alanyl histidine), composed of the amino acids of /3-alanine and L-histidine. Discovered by G. S. Gulevich in 1900 in a meat extract. Molecular weight, 226. It crystallizes into colorless needles that are readily soluble in water but insoluble in alcohol. It is found in the skeletal musculature of most vertebrates.

Carnosine and its constituent amino acids are absent in certain species of fish (only L-histidine or /3-alanine is present); it does not occur in the muscle of invertebrates. The carnosine content in the muscle of vertebrates usually varies from 200 to 400 mg percent raw muscle weight, depending on the muscular structure and function; in the human body it ranges between 100 and 150 mg percent.

Carnosine has diverse effects on the biochemical processes that occur in skeletal muscles; however, its biological role has not been definitively established. The addition of carnosine to a solution bathing the muscle of the isolated neuromyal specimen causes restoration of contractions of the fatigued muscle.

S. E. SEVERIN

References in periodicals archive ?
Oral treatment of pressure ulcers with polaprezinc (zinc L-carnosine complex): 8-week open-label trial.
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Comment: L-carnosine (beta-alanyl-L-histidine) is present in high concentrations in myocardial and muscle tissue.
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He and his colleagues observed L-carnosine levels are "markedly" higher in a transparent lens compared to one with mature cataracts: about 25 [mu]M in transparent lenses and about 5 [mu]M in those with mature cataracts.
Studies done by Nutrilite laboratories also show that this formula is significantly more effective than the two separate compounds, zinc and L-carnosine, taken together.