LDL

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LDL

(biochemistry)

LDL

["LDL: A Logic-Based Data-Language", S. Tsur et al, Proc VLDB 1986, Kyoto Japan, Aug 1986, pp.33-41].
References in periodicals archive ?
The LDL receptor. Arterioscler Thromb Vasc Biol 2009; 29: 431-438, doi: 10.1161/ ATVBAHA.108.179564.
Kootte et al., "Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis," Atherosclerosis, vol.
Furin-cleaved PCSK9 is unable to regulate the LDL receptor compared to intact PCSK9 (13).
[16] Transient down-regulation of LDL receptors in rats followed methylprednisolone administration, accounting for elevated LDL and TC.
Alternatively, the fully human monoclonal antibody PCSK9 inhibitors lower bad cholesterol by preventing PCKS9 from binding to the LDL receptors in the liver.
Alternatively, the fully human monoclonal antibody PCSK9 inhibitors lower bad cholesterol by preventing PCKS9 from binding to and degrading the LDL receptors in the liver resulting in more available to remove excess LDL cholesterol.
A nonsense mutation in the LDL receptor gene leads to familial hypercholesterolemia in the Druze sect.
The drugs are antibodies that free up a protein on cells called the LDL receptor, which lowers LDL by pulling it out of circulation.
It is thought that blocking the destructive capacity of PCSK9 can lead to more LDL receptors on cells and lower cholesterol levels.
Invasive procedures such as lipid apheresis and liver transplant may be a last resort in patients who have no functional LDL receptors and are not responding to pharmacological therapy.
Studies further reveal that it incre- ases LDL receptor binding capacity in the liver and prevents elevation of total cholesterol and up-regu- lates hepatic LDL receptors resulting in greater in- flux of plasma LDL cholesterol in the liver.
[13.] Graadt van Roggen J.F, van der Westhuyzen D.R., Coetzee G.A, Marais A.D, Steyn K., Langenhoven E., Kotze M.J., FH Afrikaner-3 LDL Receptor mutation results in defective LDL receptors and causes a mild form of familial hypercholesterolemia.