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Low-density lipoproteins are internalized by LDL receptor (LDLR) in clathrin-coated vesicles.
 Human genes: HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase; LDLR, low density lipoprotein receptor; PCSK9, proprotein convertase subtilisin/kexin type 9; NPC1L1, NPC1 like intracellular cholesterol transporter 1; ABCG5, ATP Binding Cassette Subfamily G Member 5; ABCG8, ATP Binding Cassette Subfamily G Member 8.
A total of 25 mutations in the LDLR gene were detected in 40 subjects.
Akt also regulates lipogenesis by modulating LDLR expression .
For this purpose, we blocked the receptor for nLDL (LDLR) with the anti-LDLR antibody before nLDL treatment as described by Allen et al.
The point mutation on exon 4 of LDLR gene was most common.
The molecular analysis of familial hypercholesterolemia (FH), an autosomal dominant disease caused by a multitude of LDL receptor (LDLR) gene mutations, is complicated by mutational heterogeneity of the disease in the majority of population studied to date [10,11].
Por esta circunstancia los marcadores geneticos HLA-DQA1, LDLR, GYPA, HBGG, D7S8 y GC y D1S80, han sido extensamente estudiados en varias poblaciones iberoamericanas: Argentina (Anonimo 1998, Padula et al.
Caucasian, and Hispanic samples, which were typed previously for the loci HLA-DQA1, LDLR, GYPA, HBGG, D7S8, Gc, and D1S80 (7, 8; see Table 1 of the raw data in dnaloci.txt).
The expression of low density lipoprotein receptors (LDLR) has been proven to be upregulated on the surface of many cancer cell lines, including breast cancer, prostate cancer and liver cancer (12-14).
LDLs containing only apoB-100 were shown to bind to cell-surface receptors on fibroblasts, known as the LDL receptor (LDLR) (11).
ApoE is a high affinity ligand of several hepatic lipoprotein receptors such as low-density lipoprotein receptor (LDLR) and LDL-related protein (LRP) which plays important roles in triglyceride lipoprotein and cholesterol metabolism .
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