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lysergic acid diethylamide

(lī'sûr`jĭk, dī'ĕth`ələmĭd, dī'ĕthəlăm`ĭd), alkaloid synthesized from lysergic acid, which is found in the fungus ergotergot
, disease of rye and other cereals caused by the fungus Claviceps purpurea. The cottony, matlike body, or mycelium, of the fungus develops in the ovaries of the host plant; it eventually turns into a hard pink or purple body, the sclerotium, or ergot, that resembles
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 (Claviceps purpurea). It is a hallucinogenic drughallucinogenic drug
, any of a group of substances that alter consciousness; also called psychotomimetic (i.e., mimicking psychosis), mind-expanding, or psychedelic drug.
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 that intensifies sense perceptions and produces hallucinations, mood changes, and changes in the sense of time. It also can cause restlessness, acute anxiety, and, occasionally, depression. Although lysergic acid itself is without hallucinogenic effects, lysergic acid diethylamide, one of the most powerful drugs known, is weight for weight 5,000 times as potent as the hallucinogenic drug mescaline and 200 times as potent as psilocybin. LSD is usually taken orally from little squares of blotter paper, gelatin "windowpanes," or tiny tablets called microdots. The period of its effects, or "trip," is usually 8 to 12 hours. Unexpected reappearances of the hallucinations, called "flashbacks," can occur months after taking the drug. The drug does not appear to cause psychological or physical dependence. The danger of LSD is that its effects are unpredictable, even in experienced users.


LSD was developed in 1938 by Arthur Stoll and Albert Hofmann, Swiss chemists hoping to create a headache cure. In 1943 Hofmann accidentally ingested some of the drug and discovered its hallucinogenic effect. In the 1960s and 70s it was used by millions of young people in America; its popularity waned as its reputation for bad trips and resulting accidents and suicides became known. In 1967, the federal government classified it as a Schedule I drug, i.e., having a high abuse potential and no accepted medical use, along with heroinheroin
, opiate drug synthesized from morphine (see narcotic). Originally produced in 1874, it was thought to be not only nonaddictive but useful as a cure for respiratory illness and morphine addiction, and capable of relieving morphine withdrawal symptoms.
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 and marijuanamarijuana
or marihuana,
drug obtained from the flowering tops, stems, and leaves of the hemp plant, Cannabis sativa (see hemp) or C. indica; the latter species can withstand colder climates.
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. In the early 1990s it again became popular, presumably because of its low cost. It is produced in clandestine laboratories.


See publications of the Drugs & Crime Data Center and Clearinghouse, the Bureau of Justice Statistics Clearinghouse, and the National Clearinghouse for Alcohol and Drug Information.


(naval architecture)
(organic chemistry)


lysergic acid diethylamide; a crystalline compound prepared from lysergic acid, used in experimental medicine and taken illegally as a hallucinogenic drug
References in periodicals archive ?
Enzyme Replacement Therapy (ERT) is the established treatment for LSDs and works by replacing the missing enzyme in the affected cells.
ERT has been the most successful technology to date as a treatment for LSDs followed by small molecule therapy and SRT.
About age of presentation and severity of disease, she said these vary according to the type of LSD, however, it is mostly below one year old children who present with it.
There is limited benefit for other LSDs to be included in NBS programs at this moment in light of absence of supporting evidence.
Currently, Indus Hospital, National Institute of Blood Diseases, National Institute of Child Health, Children Hospital Karachi, Children Hospital Multan, Nishter Hospital, Children Hospital Lahore, Lahore General Hospital, Combined Military Hospital Rawalpindi, Shaheed Benazir Bhutto Hospital Islamabad are equipped with LSD diagnosis and treatment facilities.
In times past, the few LSDS that existed were such that users were either forced to work with aggregates (e.g., census data), or they consisted of massive tomes (e.g., telephone directories) or huge files (e.g., real property or medical case records) from which individual records could be retrieved.
Mr Prasanna Kumar Shirol, President, LSDSS said: "A number of patients across the state of Tamil Nadu suffer from LSDs but do not have access to treatment.
" From diagnosis to treatment, it's a difficult experience, and the lack of understanding about the disease makes it even tougher," says Jawaharlal, Palak's grandfather, who is one of the frontrunners in the LSD society here.
"Tony also had an LSD which was at one time, not sure if still there, loaned to the Tolson Museum," said Mick.
Individually, each disease is rare but, as a group, the prevalence of LSDs has been estimated from one in 5,000 to one in 7,000 individuals.
LSDs are caused by defects in the enzymes responsible for recycling waste from the cells.
Many companies manufacture LSDs, including Polymer Laboratories, Eurosep, Alltech Associates (through its 1993 purchase of Varex' product line), ESA, Viscotek, Wyatt Technology, SEDERE, and Rheometric Scientific via its late 2000 purchase of Protein Solutions (see IBO 11/30/00).