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A condition of decreased alkali reserve of the blood and other body fluids.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



a change in the acid-alkaline balance of the organism as a result of insufficient removal and oxidation of organic acids (for example, beta-hydroxybutyric acid). Usually these products are rapidly removed from the body. In febrile diseases, intestinal disorders, pregnancy, starvation, and such, they are retained in the body; this is manifested in mild cases by the appearance of acetoacetic acid and acetone in the urine (so-called ketonuria). In severe cases (for example, diabetes mellitus) it may lead to coma. Treatment consists of removal of the cause of acidosis (for example, by administering insulin in case of diabetes); there is also symptomatic treatment—soda and an abundance of fluids taken internally.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
* Lactic acidosis: Patients with a decreasing pH <7.35 and decreasing bicarbonate <17 mmol/L caused by SHL.
Emergency clinicians need to have a high index of suspicion for INH overdose in patients presenting with resistant status epilepticus or unexplained lactic acidosis, and be familiar with the emergency management, as discussed above.
Lactic acidosis is defined as large anion-gap metabolic acidosis with arterial pH less than 7.35 and lactate level greater than 5 mmol/L.
Ortolani, "Induction of lactic acidosis in cattle with sucrose: relationship between dose, rumen fluid pH and animal size," Veterinary and Human Toxicology, vol.
Of the 35 patients with elevated lactate levels, 43% (n=15) were obese and 4 (11%) died due to complications of lactic acidosis.
Severe metformin intoxication with lactic acidosis in an adolescent.
It turned out that only patients with severe kidney, liver, pulmonary, or cardiac impairment had to avoid metformin because of lactic acidosis concerns, and even these worries were overblown.
Severe lactic acidosis and rhabdomyolysis following Metformin and ramipril overdose.
Each of these samples was separated and used to simulate each of the abnormal in vitro conditions; 9 tubes were used for each reaction, 3 separate 3 mL aliquots of all 3 RBC types were placed into red top Vacutainer[R] tubes, where the abnormal in vitro conditions were created; lactic acidosis and septicemia (Figure 1).
Lactic acidosis is an important cause of metabolic acidosis in hospitalised patients.