To the Editor: Langerhans cell
histiocytosis (LCH) is a rare disease that usually occurs in the first two decades of life. Multisystem-LCH (MS-LCH) mainly affects youth.
Despite apparently normal biomicroscopic and clinical findings during the prodromal period, iVCM revealed a marked increase in Langerhans cells
in the subbasal plexus in our study, indicating that inflammation has already started.
sarcoma arising from Langerhans cell
histiocytosis: a case report.
Diagnosis and management of langerhans cell
Bone marrow findings at diagnosis in patients with multisystem langerhans cell
The overall incidence of orbital Langerhans Cell
Histiocytosis is estimated to be 20%, most commonly as eosinophilic granuloma.
This classification was constructed as follows: Langerhans cell
histiocytosis (LCH), Langerhans cell
sarcoma, interdigitating dendritic cell sarcoma, follicular dendritic cell sarcoma/tumor, and other rare dendritic cell tumors (i.e., fibroblastic reticular cell tumor and indeterminate dendritic cell tumor).
Collin, "Origin, homeostasis and function of Langerhans cells
and other langerin-expressing dendritic cells," Nature Reviews Immunology, vol.
Quantification of Langerhans Cells
. Twenty representative images per animal were then randomly chosen from the whole region of interest for each time point to assess the distribution of Langerhans cells
in the skin.
(LCs), representing the DC population found in epidermis, are considered to be of nonlymphoid tissue origin, while dermal DCs derive from bone marrow and blood-borne precursors .
Caption: Figure 2: Infiltration of the edematous stroma by polygonal cells with eosinophilic cytoplasm, oval nuclei with longitudinal grooves resembling coffee beans named as Langerhans cells
, and eosinophils are observed.
Indeed, in the past we have shown in skin equivalents with integrated Langerhans Cells
(SE-LC) that upon allergen exposure MUTZ-3 LC mature and migrate in a CXCL12 dependent manner from the epidermis to the dermis, whereas upon irritant exposure MUTZ-3 LC migrate in a CCL5 dependent manner and undergo an IL-10 dependent phenotypic switch into a macrophage-like cell in the dermis, closely mimicking our observations in excised skin (Kosten et al., 2015b; Ouwehand et al., 2008, 2011b).