Langerhans cell

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Langerhans cell

[′läŋ·ər‚hänz ‚sel]
(histology)
A type of cytotrophoblast in the human chorionic vesicle which is thought to secrete chorionic gonadotropin.
A highly branched dendritic cell of the mammalian epidermis showing a lobulated nucleus and a diagnostic organelle resembling a tennis racket.
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To the Editor: Langerhans cell histiocytosis (LCH) is a rare disease that usually occurs in the first two decades of life.[1] Multisystem-LCH (MS-LCH) mainly affects youth.
Despite apparently normal biomicroscopic and clinical findings during the prodromal period, iVCM revealed a marked increase in Langerhans cells in the subbasal plexus in our study, indicating that inflammation has already started.
Langerhans cell sarcoma arising from Langerhans cell histiocytosis: a case report.
Bone marrow findings at diagnosis in patients with multisystem langerhans cell histiocytosis.
The overall incidence of orbital Langerhans Cell Histiocytosis is estimated to be 20%, most commonly as eosinophilic granuloma.
This classification was constructed as follows: Langerhans cell histiocytosis (LCH), Langerhans cell sarcoma, interdigitating dendritic cell sarcoma, follicular dendritic cell sarcoma/tumor, and other rare dendritic cell tumors (i.e., fibroblastic reticular cell tumor and indeterminate dendritic cell tumor).
Collin, "Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells," Nature Reviews Immunology, vol.
Quantification of Langerhans Cells. Twenty representative images per animal were then randomly chosen from the whole region of interest for each time point to assess the distribution of Langerhans cells in the skin.
Langerhans cells (LCs), representing the DC population found in epidermis, are considered to be of nonlymphoid tissue origin, while dermal DCs derive from bone marrow and blood-borne precursors [34].
Caption: Figure 2: Infiltration of the edematous stroma by polygonal cells with eosinophilic cytoplasm, oval nuclei with longitudinal grooves resembling coffee beans named as Langerhans cells, and eosinophils are observed.
Indeed, in the past we have shown in skin equivalents with integrated Langerhans Cells (SE-LC) that upon allergen exposure MUTZ-3 LC mature and migrate in a CXCL12 dependent manner from the epidermis to the dermis, whereas upon irritant exposure MUTZ-3 LC migrate in a CCL5 dependent manner and undergo an IL-10 dependent phenotypic switch into a macrophage-like cell in the dermis, closely mimicking our observations in excised skin (Kosten et al., 2015b; Ouwehand et al., 2008, 2011b).

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