lapachol


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lapachol

[lə′pä‚chȯl]
(biochemistry)
C15H14O3 A yellow crystalline compound obtained from lapacho, a hardwood in Argentina and Paraguay. Also known as lapachoic acid; targusic acid.
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-Pau D'Arco tea contains Lapachol, which is anti-fungal, anti-parasitic and anti-microbial, which all helps to maintain healthy red blood cells.
Among the various quinones reported in the literature, lapachol and P-lapachone are of clinical importance because they have been associated with a variety of pharmacological activities (Oswald, 1993-1994; Silva et al., 2003; Gomez Castellanos et al., 2009).
Demicheli et al., "Cytotoxicity and in vitro antileishmanial activity of antimony(V), bismuth(V), andtin(IV) complexes of lapachol," Bioinorganic Chemistry and Applications, vol.
What does it do: The inner bark contains the effective chemical ingredients which are anthraquinones, coumarins, flavanoids, iridoids and napthaquinones and contain the extract lapachol that gives rise to the remarkable claims made for this plant.
Lapachol (2, Figure 1), a prenylnaphthoquinone occurring in Central and South American species of Handroanthus spp.
The antipromastigote activity of lapachol, isolapachol, and dihydrolapachol, with soluble derivatives (potassium salt), was evaluated.
Examples of quinones which have been described as effective against Leishmania species and Trypanosoma cruzi include lapachol (Figure 1(a)), [beta]-lapachone (Figure 1(b)), and [alpha]-lapachone (Figure 1(c)), first isolated from the heartwood of trees of the Bignoniaceae family (Tabebuia sp.), and plumbagin (Figure 1(d)), extracted from Plumbago scandens L.
Vargas, Molluscicidal Activity of Synthetic Lapachol Amino and Hydrogenated Derivatives, Bioorg.
alternata) from Aegiceras corniculatum and Tabebuia argentea which produce quinones alterporriol K and lapachol, respectively.
This naphthoquinone derivative is an analogue of [beta]-lapachone, a naphthoquinone derived from lapachol isolated from Tabebuia avellanedae (Bignoniaceae), and showed anti-proliferative activity against a number of cancer cell lines such as DLD-1 and HT-29 human colon carcinoma (Ashwell et al.
Scientific name (1) Notes Chemical constituents/Countries using love potions Bignoniaceae Lapachol in genus/Trinidad and Tabebuia bahamensis Jamaica (Northrop) Britt.